Prostaglandin D2 Receptor 2 (PTGDR2) (AA 320-370) antibody

Catalog No. ABIN6991809

Product Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Binding Specificity: AA 320-370

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: PTGDR2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal PTGDR2 antibody was raised against a 19 amino acid peptide near the center of human PTGDR2. The immunogen is located within amino acids 320 - 370 of PTGDR2.

Isotype: IgG

Application Details

Application Notes: PTGDR2 antibody can be used for detection of PTGDR2 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PTGDR2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PTGDR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Alternative Name: PTGDR2 (PTGDR2 Products)

Synonyms: CD294 antibody, CRTH2 antibody, DL1R antibody, DP2 antibody, GPR44 antibody, Crth2 antibody, Grp45 antibody, Ptgdr2 antibody, Gpr44 antibody, prostaglandin D2 receptor 2 antibody, PTGDR2 antibody, Ptgdr2 antibody

Background: PTGDR2 Antibody: The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.

Molecular Weight: Predicted: 43 kDa

Gene ID: 11251

NCBI Accession: NP_004769

UniProt: Q9Y5Y4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling