RIPK3 antibody (C-Term)

Catalog No. ABIN6992283

Product Details anti-RIPK3 Antibody

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIPK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Several isoforms of hRIP3 are known to exist.

Purification: hRIP3 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-hRIP3 antibody was raised against a peptide corresponding to 18 amino acids near the carboxy terminus of human hRIP3. The immunogen is located within the last 50 amino acids of hRIP3.

Isotype: IgG

Application Details

Application Notes: WB: 0.5-1 μ,g/mL, IF: 20 μ,g/mL, IHC: 2-5 μ,g/mL.

Antibody validated: Western Blot, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: hRIP3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: hRIP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Alternative Name: hRIP3 (RIPK3 Products)

Synonyms: RIPK3 antibody, RIP3 antibody, 2610528K09Rik antibody, AW107945 antibody, Rip3 antibody, Hcyp2 antibody, receptor interacting serine/threonine kinase 3 antibody, receptor interacting serine/threonine kinase 3 S homeolog antibody, receptor-interacting serine-threonine kinase 3 antibody, RIPK3 antibody, ripk3.S antibody, Ripk3 antibody

Background: HRIP3 Antibody: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-?B activation. Overexpression of RIP3 induces apoptosis and NF-?B activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.

Molecular Weight: Predicted: 57kD

Observed: 57 kD kDa

Gene ID: 11035

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades