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HSD11B1 antibody
HSD11B1
Reactivity: Human
ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-HSD11B1 Antibody
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Target
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HSD11B1
(Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
Reactivity
All reactivities for HSD11B1 antibodies
Human
Host
All hosts for HSD11B1 antibodies
Rabbit
Clonality
All clonalities for HSD11B1 antibodies
Polyclonal
Conjugate
All conjugates for HSD11B1 antibodies
This HSD11B1 antibody is un-conjugated
Application
All applications for HSD11B1 antibodies
ELISA, Immunohistochemistry (IHC)
Characteristics
Polyclonal Antibody
Purification
Antigen affinity purification
Immunogen
Fusion protein of human HSD11B1
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
IHC 1:50-1:200, ELISA 1:5000-1:10000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.2 mg/mL
Buffer
PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for HSD11B1
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Target
HSD11B1
(Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
Alternative Name
HSD11B1 (HSD11B1 Products )
Synonyms
11-DH antibody, 11-beta-HSD1 antibody, CORTRD2 antibody, HDL antibody, HSD11 antibody, HSD11B antibody, HSD11L antibody, SDR26C1 antibody, hsd11 antibody, hsd11b antibody, LRRGT00065 antibody, hydroxysteroid 11-beta dehydrogenase 1 antibody, hydroxysteroid (11-beta) dehydrogenase 1b antibody, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog antibody, HSD11B1 antibody, HSD11B1b antibody, hsd11b1.L antibody, Hsd11b1 antibody
Background
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
UniProt
P28845
Pathways
Metabolism of Steroid Hormones and Vitamin D , Steroid Hormone Biosynthesis , Regulation of Carbohydrate Metabolic Process
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