KEAP1 antibody (AA 65-160) (Cy5.5)
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- Target See all KEAP1 Antibodies
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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Binding Specificity
- AA 65-160
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Reactivity
- Human, Mouse, Rat, Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KEAP1 antibody is conjugated to Cy5.5
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Pig, Rabbit, Rat
- Predicted Reactivity
- Dog,Cow
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human KEAP1
- Isotype
- IgG
- Top Product
- Discover our top product KEAP1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
- Alternative Name
- KEAP1 (KEAP1 Products)
- Synonyms
- INrf2 antibody, KLHL19 antibody, INRF2 antibody, mKIAA0132 antibody, Inrf2 antibody, fb36f11 antibody, keap1 antibody, wu:fb36f11 antibody, KEAP1 antibody, klhl19 antibody, zgc:171654 antibody, kelch like ECH associated protein 1 antibody, kelch-like ECH-associated protein 1 antibody, Kelch-like ECH-associated protein 1 antibody, kelch-like ECH-associated protein 1a antibody, kelch like ECH associated protein 1 L homeolog antibody, kelch-like ECH-associated protein 1b antibody, KEAP1 antibody, Keap1 antibody, keap1a antibody, keap1 antibody, keap1.L antibody, keap1b antibody
- Background
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Synonyms: INrf2, KLHL19, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, KIAA0132
Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
- Gene ID
- 9817
- UniProt
- Q14145
- Pathways
- Maintenance of Protein Location
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