Endoglin antibody (FITC)

Catalog No. ABIN7076815

Product Details anti-Endoglin Antibody (FITC)

Target: Endoglin (ENG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endoglin antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Characteristics: The clone SN6h, a mouse monoclonal antibody selectively binds to a ~95 kDa type I transmembrane homodimer glycoprotein known as CD105. It is also encoded by END (Endoglin) and belongs to the TGF-β type III receptor family. CD105 mostly expressed on vascular endothelial cells, placental syncytiotrophoblasts, mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells. CD105 works as an important regulatory component of the TGF-β receptor system. CD105 expression is increased on activated endothelium tissues undergoing angiogenesis and also in cases of wound healing or dermal inflammation. CD105 may also be involved in the solid tumor metastasis, in regulation of cytoskeletal cellular organization as well as migration.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: EDG (CD105) isolated from acute lymphoblastic leukemia cells

Clone: SN6h

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105 (ENG Products)

Synonyms: ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody

Background: The clone SN6h, a mouse monoclonal antibody selectively binds to a ~95 kDa type I transmembrane homodimer glycoprotein known as CD105. It is also encoded by END (Endoglin) and belongs to the TGF-β type III receptor family. CD105 mostly expressed on vascular endothelial cells, placental syncytiotrophoblasts, mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells. CD105 works as an important regulatory component of the TGF-β receptor system. CD105 expression is increased on activated endothelium tissues undergoing angiogenesis and also in cases of wound healing or dermal inflammation. CD105 may also be involved in the solid tumor metastasis, in regulation of cytoskeletal cellular organization as well as migration.

Gene ID: 2022

UniProt: P17813