DNMT3A antibody (pSer390, pSer393) (HRP)
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- Target See all DNMT3A Antibodies
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
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Binding Specificity
- pSer390, pSer393
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DNMT3A antibody is conjugated to HRP
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Application
- Western Blotting (WB), ELISA
- Cross-Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated Synthesised phosphopeptide derived from human Dnmt3a around the phosphorylation site of Ser390 + Ser393
- Isotype
- IgG
- Top Product
- Discover our top product DNMT3A Primary Antibody
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- Application Notes
- WB 1:300-5000
- Restrictions
- For Research Use only
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- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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- Target
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
- Alternative Name
- Dnmt3a (DNMT3A Products)
- Synonyms
- DNMT3A antibody, DNMT3A2 antibody, M.HsaIIIA antibody, MmuIIIA antibody, dnmt3a1 antibody, dnmt6 antibody, DNA methyltransferase 3 alpha antibody, DNA methyltransferase 3A antibody, DNA (cytosine-5-)-methyltransferase 3 alpha b antibody, DNMT3A antibody, Dnmt3a antibody, dnmt3a antibody, dnmt3ab antibody
- Background
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Synonyms: Dnmt3a (phospho S390 + S393), Dnmt3a (phospho Ser390 + Ser393), p-Dnmt3a (phospho S390 + S393), DNA (cytosine 5) methyltransferase 3 alpha, DNA (cytosine 5) methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, DNM3A_HUMAN, DNMT 3a, DNMT, Dnmt3a, DNMT3A2, M.HsaIIIA, MCMT, OTTHUMP00000201149.
Background: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.
- Gene ID
- 1788
- UniProt
- Q9Y6K1
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