TRKB antibody (pTyr706, pTyr707)

Catalog No. ABIN7139054

Product Details anti-TRKB Antibody

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Binding Specificity: pTyr706, pTyr707

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRKB antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 706/tyrosine 707 (T-D-Y(p)-Y(p)-R-V)derived from Human Trk B.

Isotype: IgG

Application Details

Application Notes: IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRKB

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Alternative Name: NTRK2 (NTRK2 Products)

Synonyms: trkb antibody, trkb-b antibody, xtrkb antibody, si:ch211-220b11.1 antibody, trkB2 antibody, NTRK2 antibody, ntrk2 antibody, gp145-trkb antibody, TRKB antibody, GP145-TrkB antibody, trk-B antibody, AI848316 antibody, C030027L06Rik antibody, Tkrb antibody, trkB antibody, RATTRKB1 antibody, TRKB1 antibody, Trk-B antibody, TrkB antibody, neurotrophic receptor tyrosine kinase 2 antibody, neurotrophic receptor tyrosine kinase 2 L homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2b antibody, neurotrophic receptor tyrosine kinase 2 S homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2 antibody, NTRK2 antibody, ntrk2.L antibody, ntrk2b antibody, ntrk2.S antibody, ntrk2 antibody, Ntrk2 antibody

Background:

Background:

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Nakagawara A., Genomics 25:538-546(1995).
Shelton D.L., J. Neurosci. 15:477-491(1995).
Stoilov P., Biochem. Biophys. Res. Commun. 290:1054-1065(2002).

Aliases: AI848316 antibody, BDNF tropomyosine receptor kinase B antibody, BDNF/NT 3 growth factors receptor antibody, BDNF/NT-3 growth factors receptor antibody, Brain derived neurotrophic factor receptor antibody, C030027L06Rik antibody, EC 2.7.10.1 antibody, GP145 TrkB antibody, GP145-TrkB antibody, GP145-TrkB/GP95-TrkB antibody, GP95 TrkB antibody, Neurotrophic receptor tyrosine kinase 2 antibody, Neurotrophic tyrosine kinase receptor type 2 antibody, Neurotrophin receptor tyrosine kinase type 2 antibody, NTRK 2 antibody, Ntrk2 antibody, NTRK2_HUMAN antibody, Obesity, hyperphagia, and developmental delay, included antibody, RATTRKB1 antibody, Tkrb antibody, Trk B antibody, Trk-B antibody, TRKB antibody, TrkB tyrosine kinase antibody, TRKB1 antibody, Tropomyosin related kinase B antibody, tyrosine kinase receptor B antibody, Tyrosine receptor kinase B antibody

UniProt: Q16620

Pathways: RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport