ALK antibody (AA 1402-1604)

Catalog No. ABIN7368872

Product Details anti-ALK Antibody

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Binding Specificity: AA 1402-1604

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human ALK tyrosine kinase receptor protein (1402-1604AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Alternative Name: ALK (ALK Products)

Synonyms: Tcrz antibody, CD246 antibody, NBLST3 antibody, ALK antibody, anaplastic lymphoma kinase antibody, anaplastic lymphoma receptor tyrosine kinase antibody, ALK receptor tyrosine kinase antibody, Alk antibody, ALK antibody

Background:

Background: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Aliases: Alk antibody, ALK tyrosine kinase receptor antibody, ALK/EML4 fusion gene, included antibody, ALK/NPM1 fusion gene, included antibody, ALK_HUMAN antibody, anaplastic lymphoma kinase (Ki-1) antibody, Anaplastic lymphoma kinase antibody, Anaplastic lymphoma kinase Ki1 antibody, anaplastic lymphoma receptor tyrosine kinase antibody, CD 246 antibody, CD246 antibody, CD246 antigen antibody, EC 2.7.10.1 antibody, Ki 1 antibody, Ki1 antibody, mutant anaplastic lymphoma kinase antibody, NBLST 3 antibody, NBLST3 antibody, Tcrz antibody, TFG/ALK antibody

UniProt: Q9UM73

Pathways: RTK Signaling