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CDK9 antibody (AA 153-372)

CDK9 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7148906
  • Target See all CDK9 Antibodies
    CDK9 (Cyclin-Dependent Kinase 9 (CDK9))
    Binding Specificity
    • 25
    • 15
    • 10
    • 10
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 153-372
    Reactivity
    • 96
    • 46
    • 20
    • 7
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Human
    Host
    • 92
    • 4
    • 2
    Rabbit
    Clonality
    • 86
    • 12
    Polyclonal
    Conjugate
    • 39
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CDK9 antibody is un-conjugated
    Application
    • 75
    • 31
    • 26
    • 26
    • 15
    • 12
    • 11
    • 8
    • 8
    • 7
    • 3
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Cyclin-dependent kinase 9 protein (153-372AA)
    Isotype
    IgG
    Top Product
    Discover our top product CDK9 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CDK9 (Cyclin-Dependent Kinase 9 (CDK9))
    Alternative Name
    CDK9 (CDK9 Products)
    Synonyms
    C-2k antibody, CDC2L4 antibody, CTK1 antibody, PITALRE antibody, TAK antibody, wu:fb22e09 antibody, wu:fc06c02 antibody, c-2k antibody, cdc2l4 antibody, cdk9 antibody, ctk1 antibody, pitalre antibody, tak antibody, CDK9 antibody, CG5179 antibody, Dmel\\CG5179 antibody, P-TEF antibody, P-TEFb antibody, PTefb antibody, cyclin dependent kinase 9 antibody, cyclin-dependent kinase 9 (CDC2-related kinase) antibody, cyclin-dependent kinase 9 L homeolog antibody, cyclin-dependent kinase 9 antibody, Cyclin-dependent kinase 9 antibody, cyclin-dependent kinase 9 S homeolog antibody, CDK9 antibody, cdk9 antibody, cdk9.L antibody, Cdk9 antibody, cdk9.S antibody
    Background

    Background: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein, the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on \\\'Ser-2\\\' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.

    Aliases: C-2K antibody, CDC2 related kinase antibody, CDC2L4 antibody, Cdk 9 antibody, Cdk9 antibody, CDK9_HUMAN antibody, Cell division cycle 2-like protein kinase 4 antibody, Cell division protein kinase 9 antibody, CTK1 antibody, Cyclin dependent kinase 9 antibody, Cyclin-dependent kinase 9 antibody, PITALRE antibody, Serine/threonine-protein kinase PITALRE antibody, TAK antibody, Tat associated kinase complex catalytic subunit antibody

    UniProt
    P50750
    Pathways
    Cell Division Cycle
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