Leptin Receptor antibody (AA 874-1075) (HRP)

Catalog No. ABIN7157996

Product Details anti-Leptin Receptor Antibody (HRP)

Target: Leptin Receptor (LEPR)

Binding Specificity: AA 874-1075

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Leptin Receptor antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Leptin receptor protein (874-1075AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Leptin Receptor

Target: Leptin Receptor (LEPR)

Alternative Name: LEPR (LEPR Products)

Synonyms: CD295 antibody, LEP-R antibody, LEPRD antibody, OB-R antibody, OBR antibody, obr antibody, cd295 antibody, ob-rb antibody, Fa antibody, LEPROT antibody, Leprb antibody, Modb1 antibody, OB-RGRP antibody, Obr antibody, db antibody, diabetes antibody, obese-like antibody, obl antibody, ObRb antibody, Ob-R antibody, Ob-RM antibody, lepr antibody, leptin receptor antibody, leptin receptor S homeolog antibody, LEPR antibody, lepr antibody, Lepr antibody, lepr.S antibody

Background:

Background: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).

Aliases: CD 295 antibody, CD295 antibody, CD295 antigen antibody, Db antibody, Fa antibody, HuB219 antibody, LEP R antibody, LEP-R antibody, LEPR antibody, LEPR_HUMAN antibody, LEPRD antibody, Leptin receptor antibody, Leptin receptor fatty antibody, Leptin receptor gene related protein antibody, Leptin receptor precursor antibody, Leptin receptor precursor antibody, OB R gene related protein antibody, OB receptor antibody, OB-R antibody, OB-RGRP antibody, obl antibody, Obr antibody

UniProt: P48357

Pathways: JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour