LAT antibody (AA 28-233)

Catalog No. ABIN7361948

Product Details anti-LAT Antibody

Target: LAT (Linker For Activation of T Cells (LAT))

Binding Specificity: AA 28-233

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAT antibody is un-conjugated

Application: ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Linker for activation of T-cells family member 1 protein (28-233AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LAT

Target: LAT (Linker For Activation of T Cells (LAT))

Alternative Name: LAT (LAT Products)

Synonyms: LAT antibody, lat antibody, LAT1 antibody, pp36 antibody, linker for activation of T-cells antibody, linker for activation of T cells antibody, LAT antibody, lat antibody, Lat antibody

Background:

Background: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Aliases: 36 kDa phospho tyrosine adapter protein antibody, 36 kDa phospho-tyrosine adapter protein antibody, 36 kDa phospho-tyrosine adaptor protein antibody, LAT 1 antibody, lat antibody, LAT_HUMAN antibody, LAT1 antibody, Linker for activation of T cells antibody, Linker for activation of T cells family member 1 antibody, linker for activation of T cells, transmembrane adaptor antibody, Linker for activation of T-cells family member 1 antibody, p36 38 antibody, p36-38 antibody, pp36 antibody

UniProt: O43561

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway