LAT antibody (AA 28-233)
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- Target See all LAT Antibodies
- LAT (Linker For Activation of T Cells (LAT))
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Binding Specificity
- AA 28-233
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LAT antibody is un-conjugated
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Linker for activation of T-cells family member 1 protein (28-233AA)
- Isotype
- IgG
- Top Product
- Discover our top product LAT Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- LAT (Linker For Activation of T Cells (LAT))
- Alternative Name
- LAT (LAT Products)
- Synonyms
- LAT antibody, lat antibody, LAT1 antibody, pp36 antibody, linker for activation of T-cells antibody, linker for activation of T cells antibody, LAT antibody, lat antibody, Lat antibody
- Background
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Background: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Aliases: 36 kDa phospho tyrosine adapter protein antibody, 36 kDa phospho-tyrosine adapter protein antibody, 36 kDa phospho-tyrosine adaptor protein antibody, LAT 1 antibody, lat antibody, LAT_HUMAN antibody, LAT1 antibody, Linker for activation of T cells antibody, Linker for activation of T cells family member 1 antibody, linker for activation of T cells, transmembrane adaptor antibody, Linker for activation of T-cells family member 1 antibody, p36 38 antibody, p36-38 antibody, pp36 antibody
- UniProt
- O43561
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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