ROBO1 antibody (AA 29-143) (FITC)
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- Target See all ROBO1 Antibodies
- ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
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Binding Specificity
- AA 29-143
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ROBO1 antibody is conjugated to FITC
- Application
- Please inquire
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Roundabout homolog 1 protein (29-143AA)
- Isotype
- IgG
- Top Product
- Discover our top product ROBO1 Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
- Alternative Name
- ROBO1 (ROBO1 Products)
- Synonyms
- DUTT1 antibody, SAX3 antibody, AW494633 antibody, AW742721 antibody, Gm310 antibody, ROBO1 antibody, dutt1 antibody, roundabout antibody, sax3 antibody, MGC122264 antibody, roundabout-1 antibody, roundabout guidance receptor 1 antibody, roundabout, axon guidance receptor, homolog 1 (Drosophila) antibody, roundabout guidance receptor 1 L homeolog antibody, ROBO1 antibody, Robo1 antibody, robo1 antibody, robo1.L antibody
- Background
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Background: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B, inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).
Aliases: Deleted in U twenty twenty antibody, DUTT 1 antibody, DUTT1 antibody, FLJ21882 antibody, H Robo 1 antibody, H-Robo-1 antibody, hRobo 1 antibody, Robo 1 antibody, Robo1 antibody, ROBO1_HUMAN antibody, Roundabout 1 antibody, Roundabout axon guidance receptor homolog 1 antibody, Roundabout homolog 1 antibody, Roundabout homolog1 precurser antibody, Roundabout1 antibody, SAX 3 antibody, SAX3 antibody
- UniProt
- Q9Y6N7
- Pathways
- Positive Regulation of Endopeptidase Activity
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