PTPN22 antibody (AA 1-179) (Biotin)

Catalog No. ABIN7380896

Product Details anti-PTPN22 Antibody (Biotin)

Target: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Binding Specificity: AA 1-179

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN22 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PTPN22

Target: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Alternative Name: PTPN22 (PTPN22 Products)

Synonyms: 70zpep antibody, PEP antibody, Ptpn8 antibody, LYP antibody, LYP1 antibody, LYP2 antibody, PTPN8 antibody, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) antibody, protein tyrosine phosphatase, non-receptor type 22 antibody, Ptpn22 antibody, PTPN22 antibody

Background:

Background: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating \'Tyr-394\' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating \'Tyr-493\' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).

Aliases: Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody, Lymphoid phosphatase antibody, Lymphoid specific protein tyrosine phosphatase antibody, lymphoid-specific, inducible human protein tyrosine phosphatase antibody, Lyp 1 antibody, Lyp 2 antibody, LyP antibody, Lyp1 antibody, Lyp2 antibody, LyPTP antibody, OTTHUMP00000013720 antibody, OTTHUMP00000013721 antibody, OTTHUMP00000233450 antibody, OTTHUMP00000233451 antibody, PEP antibody, PEST-domain phosphatase antibody, Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody, Protein tyrosine phosphatase non receptor type 22 antibody, Protein tyrosine phosphatase non receptor type 8 antibody, Protein tyrosine phosphatase non receptor type 8, formerly antibody, PTN22_HUMAN antibody, PTPN 22 antibody, PTPN 8 antibody, Ptpn22 antibody, PTPN8 antibody, PTPN8, formerly antibody, Tyrosine-protein phosphatase non-receptor type 22 antibody

UniProt: Q9Y2R2