CACNA1C antibody (AA 1755-1971) (Biotin)
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- Target See all CACNA1C Antibodies
- CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))
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Binding Specificity
- AA 1755-1971
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CACNA1C antibody is conjugated to Biotin
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1C protein (1755-1971AA)
- Isotype
- IgG
- Top Product
- Discover our top product CACNA1C Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))
- Alternative Name
- CACNA1C (CACNA1C Products)
- Synonyms
- CACH2 antibody, CACN2 antibody, CACNL1A1 antibody, CCHL1A1 antibody, CaV1.2 antibody, LQT8 antibody, TS antibody, Cav1.2 antibody, Cchl1a1 antibody, MBC antibody, MELC-CC antibody, RATIVS302 antibody, isl antibody, C-LTCC antibody, CHCACHA1C antibody, ICA antibody, cav1.2 antibody, ca(v)1.2 antibody, CAV1.2 antibody, BCR antibody, rbc antibody, calcium voltage-gated channel subunit alpha1 C antibody, calcium channel, voltage-dependent, L type, alpha 1C subunit antibody, voltage-dependent L-type calcium channel subunit alpha-1C antibody, calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog antibody, Red blood cell count antibody, RNA, 7SL, cytoplasmic 263, pseudogene antibody, CACNA1C antibody, Cacna1c antibody, cacna1c antibody, LOC100442085 antibody, cacna1c.S antibody, RBC antibody, RN7SL263P antibody
- Background
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Background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the \'high-voltage activated\' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
Aliases: alpha-1 polypeptide antibody, cardiac muscle antibody, isoform 1 antibody, L type antibody, CAC1C_HUMAN antibody, CACH 2 antibody, CACH2 antibody, CACN 2 antibody, CACN2 antibody, CACNA1C antibody, CACNL1A1 antibody, Calcium channel antibody, Calcium channel cardic dihydropyridine sensitive alpha 1 subunit antibody, Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle antibody, Calcium channel voltage dependent L type alpha 1C subunit antibody, CaV1.2 antibody, CCHL1A1 antibody, DHPR alpha 1 antibody, DHPR alpha 1 subunit antibody, LQT8 antibody, TS antibody, Voltage dependent L type calcium channel alpha 1C subunit antibody, Voltage dependent L type calcium channel subunit alpha 1C antibody, Voltage gated calcium channel alpha subunit Cav1.2 antibody, Voltage gated calcium channel subunit alpha Cav1.2 antibody, Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10* antibody, Voltage-dependent L-type calcium channel subunit alpha-1C antibody, Voltage-gated calcium channel subunit alpha Cav1.2 antibody
- UniProt
- Q13936
- Pathways
- Hormone Transport, Carbohydrate Homeostasis
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