DIO3 antibody (AA 37-278) (Biotin)

Catalog No. ABIN7179091

Product Details anti-DIO3 Antibody (Biotin)

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Binding Specificity: AA 37-278

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIO3 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Rat Thyroxine 5-deiodinase protein (37-278AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DIO3

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Alternative Name: Dio3 (DIO3 Products)

Synonyms: 5DIII antibody, DIOIII antibody, txdi3 antibody, dioiii antibody, XL-15 antibody, itdi3 antibody, D3 antibody, TXDI3 antibody, iodothyronine deiodinase 3 antibody, deiodinase, iodothyronine, type 3 antibody, deiodinase, iodothyronine, type III antibody, deiodinase, iodothyronine type III antibody, deiodinase, iodothyronine, type 3 L homeolog antibody, DIO3 antibody, dio3 antibody, Dio3 antibody, dio3.L antibody

Background:

Background: Responsible for the deiodination of T4 (3,5,3\\\',5\\\'-tetraiodothyronine) into RT3 (3,3\\\',5\\\'-triiodothyronine) and of T3 (3,5,3\\\'-triiodothyronine) into T2 (3,3\\\'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

Aliases: Dio3 antibody, Itdi3 antibody, Txdi3 antibody, Thyroxine 5-deiodinase antibody, EC 1.21.99.3 antibody, 5DIII antibody, DIOIII antibody, Type 3 DI antibody, Type III iodothyronine deiodinase antibody

UniProt: P49897

Pathways: Hormone Activity