LILRB4 antibody (AA 22-259)

Catalog No. ABIN7193750

Product Details anti-LILRB4 Antibody

Target: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Binding Specificity: AA 22-259

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LILRB4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant fragment of human CD85K (AA: 22-259) expressed in E. coli.

Clone: 8F1H11

Isotype: IgG1

Application Details

Application Notes: WB:1:500 - 1:2000, IHC:1:200 - 1:1000, ICC:1:200 - 1:1000, FCM:1:200 - 1:400, ELISA:1:10000,

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for LILRB4

Target: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Alternative Name: CD85K (LILRB4 Products)

Synonyms: CD85K antibody, ILT-3 antibody, ILT3 antibody, LIR-5 antibody, LIR5 antibody, Gp49b antibody, HM18 antibody, gp49 antibody, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 antibody, leukocyte immunoglobulin like receptor B4 antibody, leukocyte immunoglobulin-like receptor, subfamily B, member 4A antibody, LILRB4 antibody, Lilrb4a antibody

Background:

Description: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Aliases: ILT3, LIR5, LILRB4, ILT-3, LIR-5

Molecular Weight: 49 kDa

Gene ID: 11006