FOXO3 antibody

Catalog No. ABIN7228548

The Rabbit Polyclonal anti-FOXO3 antibody (ABIN7228548) specifically detects FOXO3 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for FOXO3 antibody (ABIN7228548)

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FOXO3 Antibody

Purpose: Rabbit Anti-FKHRL1 Polyclonal Antibody

Specificity: This antibody detects endogenous levels of FKHRL1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human FKHRL1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FOXO3

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Alternative Name: FKHRL1

Background: Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1FOXO3 (Forkhead Box O3) is a Protein Coding gene. Diseases associated with FOXO3 include Rhabdomyosarcoma and Cervix Carcinoma. Among its related pathways are IL-2 Pathway and Longevity regulating pathway. FOXO3 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXO3 likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of FOXO3 with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Molecular Weight: 65kD

Gene ID: 2309

UniProt: O43524

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis