BAD antibody (pSer112)

Catalog No. ABIN7265846

The Rabbit Monoclonal anti-BAD antibody is suitable to detect BAD in samples from Human. It has been validated for WB.

Quick Overview for BAD antibody (pSer112) (ABIN7265846)

Target: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BAD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAD Antibody

Binding Specificity: pSer112

Purpose: Phospho-Bad-S112 Rabbit mAb

Cross-Reactivity: Human, Mouse

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding S112 of human Bad

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for BAD

Target: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Alternative Name: BAD

Background: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008],BBC2, BCL2L8,Apoptosis,Apoptosis_Bcl 2 family,Apoptosis_Inhibition of Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Cancer,Cell Biology & Developmental Biology,Endocrine & Metabolism,ErbB-HER Signaling Pathway,Immunology & Inflammation,Insulin Receptor Signaling Pathway,Invasion and Metastasis,MAPK-Erk Signaling Pathway,Neurodegenerative Diseases,Neuroscience,PI3K-Akt Signaling Pathway,Protein phosphorylation,Signal Transduction,BAD

Molecular Weight: 23kDa

Gene ID: 572

UniProt: Q92934

Pathways: MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, Apoptosis, Fc-epsilon Receptor Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events