DAXX antibody

Catalog No. ABIN7266713

Product Details anti-DAXX Antibody

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This DAXX antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Daxx Rabbit mAb

Cross-Reactivity: Human

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Daxx

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Alternative Name: DAXX (DAXX Products)

Synonyms: BING2 antibody, DAP6 antibody, EAP1 antibody, LOC100226911 antibody, daxx antibody, si:dz179b20.7 antibody, wu:fd15c03 antibody, death domain associated protein antibody, Fas death domain-associated protein antibody, 28S ribosomal protein S29, mitochondrial antibody, death-domain associated protein antibody, death-associated protein 6 L homeolog antibody, DAXX antibody, Daxx antibody, LOC100226911 antibody, daxx.L antibody, daxx antibody

Background: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008],BING2, DAP6, EAP1,Apoptosis,Cell Biology & Developmental Biology,Chromatin Remodeling,Death Receptor Signaling Pathway,Epigenetics & Nuclear Signaling,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Neurodegenerative Diseases,Neuroscience,Signal Transduction,DAXX

Molecular Weight: 81kDa

Gene ID: 1616

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway