GTPase NRas antibody

Catalog No. ABIN7267531

This Rabbit Monoclonal antibody specifically detects GTPase NRas in WB and IF. It exhibits reactivity toward Human.

Quick Overview for GTPase NRas antibody (ABIN7267531)

Target: GTPase NRas (NRAS)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GTPase NRas antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-GTPase NRas Antibody

Purpose: NRAS Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human NRAS

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GTPase NRas

Target: GTPase NRas (NRAS)

Alternative Name: NRAS

Background: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011],ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6,Cancer,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Actins,Endocrine & Metabolism,ErbB-HER Signaling Pathway,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,G protein signaling_Small G proteins,IL-6 Receptor Signaling Pathway,Immunology & Inflammation,Insulin Receptor Signaling Pathway,MAPK-Erk Signaling Pathway,MAPK-JNK Signaling Pathway,NF-kB Signaling Pathway,Signal Transduction,T Cell Receptor Signaling Pathway,Warburg Effect,NRAS

Molecular Weight: 18kDa

Gene ID: 4893

UniProt: P01111, P01112

Pathways: p53 Signaling, MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling