PPARGC1A antibody (C-Term)

Catalog No. ABIN7529539

Product Details anti-PPARGC1A Antibody

Target: PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPARGC1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purpose: PGC1α Rabbit pAb

Sequence: FGEIEECTVN LRDDGDSYGF ITYRYTCDAF AALENGYTLR RSNETDFELY FCGRKQFFKS NYADLDSNSD DFDPASTKSK YDSLDFDSLL KEAQRSLRR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 700 to the C-terminus of human PGC1alpha (NP_037393.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PPARGC1A

Target: PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A))

Alternative Name: PPARGC1A (PPARGC1A Products)

Synonyms: PPARGC1A antibody, PPARGC1 antibody, A830037N07Rik antibody, ENSMUSG00000079510 antibody, Gm11133 antibody, PGC-1 antibody, PGC-1v antibody, Pgc-1alpha antibody, Pgc1 antibody, Pgco1 antibody, Ppargc1 antibody, PGC1 antibody, PGC1A antibody, LEM6 antibody, PGC-1(alpha) antibody, AVPGC-1ALPHA antibody, PPARG coactivator 1 alpha antibody, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha antibody, PPARG coactivator 1 alpha S homeolog antibody, PPARGC1A antibody, Ppargc1a antibody, ppargc1a.S antibody

Background: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.,PPARGC1A,LEM6,PGC-1(alpha),PGC-1alpha,PGC-1v,PGC1,PGC1A,PPARGC1,PPARG coactivator 1 alpha,PGC1 alpha,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cancer,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial Biogenesis,Nucleotide metabolism,Molecular processes,AMPK Signaling Pathway,Endocrine and metabolic diseases,Diabetes,Obesity,Neuroscience,Neurodegenerative Diseases,Cardiovascular,Lipids,Fatty Acids,PPARGC1A

Molecular Weight: 14kDa/30kDa/31kDa/33kDa/77kDa/89kDa/91kDa

Gene ID: 10891

UniProt: Q9UBK2

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Brown Fat Cell Differentiation