PKC zeta antibody (pThr560)

Catalog No. ABIN7269640

Product Details anti-PKC zeta Antibody

Target: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Binding Specificity: pThr560

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PKC zeta antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Phospho-PKC zeta-T560 Rabbit mAb

Cross-Reactivity: Human, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding T560 of human PKC zeta

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PKC zeta

Target: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Alternative Name: PRKCZ (PRKCZ Products)

Synonyms: TPKC antibody, PKCzeta antibody, prkcz-A antibody, pkc-zeta antibody, PRKCZ antibody, pkc2 antibody, PKC-ZETA antibody, PKC2 antibody, AI098070 antibody, C80388 antibody, Pkcz antibody, R74924 antibody, aPKCzeta antibody, zetaPKC antibody, 14-3-3-zetaisoform antibody, r14-3-3 antibody, pkcz antibody, si:ch211-150o23.4 antibody, protein kinase C zeta L homeolog antibody, protein kinase C zeta antibody, protein kinase C, zeta antibody, prkcz.L antibody, PRKCZ antibody, prkcz antibody, Prkcz antibody

Background: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],PKC-ZETA, PKC2,Apoptosis,Apoptosis_Inhibition of Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,B Cell Receptor Signaling Pathway,Cell Biology & Developmental Biology,Endocrine & Metabolism,ErbB-HER Signaling Pathway,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Immunology & Inflammation,Insulin Receptor Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,MAPK-Erk Signaling Pathway,NF-kB Signaling Pathway,Phospholipase Signaling Pathway,Protein Kinase C Signaling Pathway Pathway,Signal Transduction,TGF-b-Smad Signaling Pathway,PRKCZ

Molecular Weight: 68kDa

Gene ID: 5590

UniProt: Q05513

Pathways: NF-kappaB Signaling, RTK Signaling, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling