Gp140trk,High affinity nerve growth factor receptor,High affinity nerve growth factor receptor precursor,MTC,Neurotrophic tyrosine kinase receptor type 1,NTRK1,NTRK1,Oncogene TRK,p14-TrkA,p140 TrkA,p140-TrkA,Slow nerve growth,Trk A,TRK,Trk-A,TRK1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor A,Tyrosine kinase receptor,This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.