c-MYC antibody

Catalog No. ABIN7384328

This Rabbit Monoclonal antibody specifically detects c-MYC in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for c-MYC antibody (ABIN7384328)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This c-MYC antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R05-5E2

Product Details anti-c-MYC Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Alternative Name: c Myc

Background: AU016757,Avian myelocytomatosis viral oncogene homolog,bHLHe39,c Myc,Class E basic helix-loop-helix protein 39,MRTL,Myc,Myc protein,Myc proto oncogene protein,Myc proto-oncogene protein,myc-related translation/localization regulatory factor,MYC,Myc2,MYCC,Myelocytomatosis oncogene,Niard,Nird,Oncogene Myc,OTTHUMP00000158589,Proto-oncogene c-Myc,Protooncogene homologous to myelocytomatosis virus,RNCMYC,Transcription factor p64,Transcriptional regulator Myc-A,V-Myc avian myelocytomatosis viral oncogene homolog,v-myc myelocytomatosis viral oncogene homolog (avian),This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Molecular Weight:

Observed_MW: 57-65kDa

Calculated_MW: 49kDa

Gene ID: 4609

UniProt: P01106

Pathways: p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect