STAT1 antibody (pTyr701) (FITC)

Catalog No. ABIN732630

Cited in 1 publication. The FITC-conjugated Rabbit Polyclonal anti-STAT1 antibody (ABIN732630) specifically detects STAT1 in FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for STAT1 antibody (pTyr701) (FITC) (ABIN732630)

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT1 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-STAT1 Antibody (FITC)

Binding Specificity: pTyr701

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human STAT1 around the phosphorylation site of tyrosine 701

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-STAT1 antibody (FITC) (ABIN732630)

Iriyama, Hatta, Takei: "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes." in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, (2016) (PubMed).

Target Details for STAT1

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Alternative Name: Stat1

Background:

Synonyms: STAT1Tyr701, signal transducers and activators of transcription 1, DKFZp686B04100, ISGF 3, Phosphorylated Stat1pTyr701, Signal transducer and activator of transcription 1 91 kDa, Signal transducer and activator of transcription 1 alpha/beta, STAT 1, STAT 91, STAT91, Transcription factor ISGF 3 components p91 p84.

Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].

Gene ID: 6772

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events