Recombinant c-MYC antibody (pSer62)

Catalog No. ABIN7828408

This Rabbit Monoclonal antibody specifically detects c-MYC in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant c-MYC antibody (pSer62) (ABIN7828408)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This c-MYC antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A816

Product Details anti-c-MYC Antibody

Binding Specificity: pSer62

Purpose: Recombinant Phospho-c-Myc (Ser62) Monoclonal Antibody

Purification: Protein A purified

Immunogen: phosphorylated human c-Myc (Ser62) peptide

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Alternative Name: c-Myc

Background: BHLHe,MYC BHLHE,MRTL,MYCC,bHLHe39,c-Myc,MYC,MYC BHLHE39,AU016757,Avian myelocytomatosis viral oncogene homolog,c Myc,Class E basic helix-loop-helix protein 39,Myc protein,Myc proto oncogene protein,Myc proto-oncogene protein,Myc2,myc-related translation/localization regulatory factor,Myelocytomatosis oncogene,Niard,Nird,Oncogene Myc,OTTHUMP00000158589,Proto-oncogene c-Myc,Protooncogene homologous to myelocytomatosis virus,RNCMYC,Transcription factor p64,Transcriptional regulator Myc-A,V-Myc avian myelocytomatosis viral oncogene homolog,v-myc myelocytomatosis viral oncogene homolog (avian),V-myc myelocytomatosis viral oncogene homolog(avian),Myc, also known as c-Myc, together with l-Myc and n-Myc, belongs to the Myc family of transcription factors. Myc has a basic helix-loop-helix leucine zipper domain and through heterodimerization can bind and regulate the transcriptional activity of genes. It is a key player in the regulation of cell growth and cell cycle progression and acts as a proto-oncogene. Myc localizes to the nucleus but can also be present in the cytoplasm of certain cancer types. Myc is ubiquitously expressed in almost all cell types and its expression positively correlates with tissue proliferative capacity. Myc is also expressed during embryogenesis. Myc is upregulated in many cancer types, especially in aggressive, poorly differentiated tumors. Mutations in the MYC gene and breakpoint translocations within the MYC gene cause Burkitt lymphoma. In addition, Myc is subject to various post-translational modifications, including phosphorylation, acetylation, and ubiquitinylation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 49 kDa

Observed MW: 55 kDa The actual band is not consistent with the expectation.

UniProt: P01106

Pathways: p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect