Neurofibromin 1 antibody (AA 160-270)

Catalog No. ABIN7871100

The Mouse Monoclonal anti-Neurofibromin 1 antibody is suitable to detect Neurofibromin 1 in samples from Human, Mouse and Rat. It has been validated for WB, IF, IHC (p) and FACS.

Quick Overview for Neurofibromin 1 antibody (AA 160-270) (ABIN7871100)

Target: Neurofibromin 1 (NF1)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neurofibromin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 4F8B7

Product Details anti-Neurofibromin 1 Antibody

Binding Specificity: AA 160-270

Purpose: NF1 Antibody / Neurofibromin

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids R160-Q270) was used as the immunogen for the NF1 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the NF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Alternative Name: NF1

Background: Neurofibromin 1 (NF1) is a gene in humans that is located on chromosome 17. This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity