Neurofibromin 1 antibody (AA 160-270)

Catalog No. ABIN7871101

The Mouse Monoclonal anti-Neurofibromin 1 antibody (Clone 4C6F10) (ABIN7871101) specifically detects Neurofibromin 1 in WB, IHC (p) and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Neurofibromin 1 antibody (AA 160-270) (ABIN7871101)

Target: Neurofibromin 1 (NF1)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neurofibromin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 4C6F10

Product Details anti-Neurofibromin 1 Antibody

Binding Specificity: AA 160-270

Purpose: Neurofibromin Antibody / NF1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R160-Q270) was used as the immunogen for the Neurofibromin antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Neurofibromin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Neurofibromin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Alternative Name: Neurofibromin

Background: Neurofibromin 1 (NF1) is a gene in humans that is located on chromosome 17. This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity