GTPase NRas antibody

Catalog No. ABIN7880943

The Rabbit Monoclonal anti-GTPase NRas antibody is suitable to detect GTPase NRas in samples from Human and Rat. It has been validated for WB.

Quick Overview for GTPase NRas antibody (ABIN7880943)

Target: GTPase NRas (NRAS)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GTPase NRas antibody is un-conjugated

Application: Western Blotting (WB)

Clone: DBC-14

Product Details anti-GTPase NRas Antibody

Purpose: NRAS Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human NRAS was used as the immunogen for the NRAS antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NRAS antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the NRAS antibody at -20oC.

Target Details for GTPase NRas

Target: GTPase NRas (NRAS)

Alternative Name: NRAS

Background: NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. It has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in the gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [RefSeq]

UniProt: P01111

Pathways: p53 Signaling, MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling