c-MET antibody (AA 208-407) (Fluoro488)

Catalog No. ABIN8009289

The Rabbit Polyclonal anti-c-MET antibody is suitable to detect c-MET in samples from Human and Rat. It has been validated for FACS.

Quick Overview for c-MET antibody (AA 208-407) (Fluoro488) (ABIN8009289)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-c-MET Antibody (Fluoro488)

Binding Specificity: AA 208-407

Purpose: Anti-Met (c-Met) Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Met shares 90%,91% amino acid (aa) sequences identity with mouse,rat Met,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Met recombinant protein (Position: D208-S407). Human Met shares 90% and 91% amino acid (aa) sequences identity with mouse and rat Met, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: MET

Background:

Background: c-Met, also called MET and hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. It is mapped to 7q31.2. The protein possesses tyrosine kinase activity. MET is a membrane receptor that is essential for embryonic development and wound healing. It induces several biological responses that collectively give rise to a program known as invasive growth. MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.

Gene Full Name: MET proto-oncogene, receptor tyrosine kinase

Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.

Gene ID: 4233

UniProt: P08581

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor