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NFKBIA antibody (pTyr42)
NFKBIA
Reactivity: Human, Mouse, Rat
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NFKBIA Antibody
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Target
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NFKBIA
(Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
Binding Specificity
All epitopes for NFKBIA antibodies
pTyr42
Reactivity
All reactivities for NFKBIA antibodies
Human, Mouse, Rat
Host
All hosts for NFKBIA antibodies
Rabbit
Clonality
All clonalities for NFKBIA antibodies
Polyclonal
Conjugate
All conjugates for NFKBIA antibodies
This NFKBIA antibody is un-conjugated
Application
All applications for NFKBIA antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous levels of IkB-a only when phosphorylated at tyrosine 42.
Purification
Affinity purified
Immunogen
Peptide sequence around phosphorylation site of pTyr42 (E-E-Y (p) -E-Q) derived from Human IkB-a Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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Discover our top product NFKBIA Primary Antibody
Alternatives
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anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) (AA 1-120) antibody
NFKBIA
Reactivity: Human, Mouse, Rat, Cow, Chicken
WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Western blotting: 1:500-1:1000 Immunohistochemistry: 1:50-1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target Details for NFKBIA
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Target
NFKBIA
(Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
Alternative Name
IkappaB-alpha (NFKBIA Products )
Synonyms
IKBA antibody, MAD-3 antibody, NFKBI antibody, AI462015 antibody, Nfkbi antibody, RL/IF-1 antibody, ECI-6/IKBA antibody, NFKBIA antibody, ikbaB antibody, wu:fb81f08 antibody, zgc:56666 antibody, zgc:77616 antibody, ikbaA antibody, wu:fj16a07 antibody, zgc:85769 antibody, NFKB inhibitor alpha antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a antibody, NFKBIA antibody, Nfkbia antibody, nfkbiab antibody, nfkbiaa antibody
Background
InhibitstheactivityofdimericNF-kappa-B/RELcomplexesbytrappingRELdimersinthecytoplasmthroughmaskingoftheirnuclearlocalizationsignals.Oncellularstimulationbyimmuneandproinflammatoryresponses,becomesphosphorylatedpromotingubiquitinationanddegradation,enablingthedimericRELAtotranlocatetothenucleusandactivatetranscription.B
Molecular Weight
39 kDa
Gene ID
4792
NCBI Accession
NP_065390
UniProt
P25963
Pathways
NF-kappaB Signaling , TCR Signaling , TLR Signaling , Fc-epsilon Receptor Signaling Pathway , Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Maintenance of Protein Location , Hepatitis C , Protein targeting to Nucleus , Toll-Like Receptors Cascades , BCR Signaling
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