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E2F1 antibody (AA 430-434)
E2F1
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-E2F1 Antibody
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Target
See all E2F1 Antibodies
E2F1
(E2F Transcription Factor 1 (E2F1))
Binding Specificity
All epitopes for E2F1 antibodies
AA 430-434
Reactivity
All reactivities for E2F1 antibodies
Human, Mouse
Host
All hosts for E2F1 antibodies
Rabbit
Clonality
All clonalities for E2F1 antibodies
Polyclonal
Conjugate
All conjugates for E2F1 antibodies
This E2F1 antibody is un-conjugated
Application
All applications for E2F1 antibodies
Western Blotting (WB)
Specificity
The antibody detects endogenous levels of total E2F-1 protein.
Purification
Affinity purified
Immunogen
Peptide sequence around AA 430-434 (G-D-L-T-P) derived from Human E2F-1 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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Alternatives
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Application Details
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Application Notes
Western blotting: 1:500-1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target Details for E2F1
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Target
E2F1
(E2F Transcription Factor 1 (E2F1))
Alternative Name
E2F-1 (E2F1 Products )
Synonyms
CG6376 antibody, DRTF1/E2F antibody, DmE2F-1 antibody, Dmel\\CG6376 antibody, Dp antibody, E(Sev-CycE)3A antibody, E(var)3-93E antibody, E(var)3-95E antibody, E(var)93E antibody, E2F antibody, E2F-1 antibody, E2F1 antibody, E2f1 antibody, Evar(3)164 antibody, dE2F antibody, dE2F1 antibody, dE2f antibody, dE2f1 antibody, de2f1 antibody, def21 antibody, drosE2F1 antibody, e2f antibody, e2f1 antibody, l(3)07172 antibody, l(3)j3B1 antibody, l(3)j3C2 antibody, l(3)rM729 antibody, RBAP1 antibody, RBBP3 antibody, RBP3 antibody, mKIAA4009 antibody, xE2F antibody, ATE2FB antibody, E2F TRANSCRIPTION FACTOR-1 E2F1 antibody, E2F transcription factor 1 antibody, E2FB antibody, E2FB TRANSCRIPTION FACTOR antibody, E2F transcription factor 1 antibody, E2F transcription factor 1 L homeolog antibody, E2f1 antibody, E2F1 antibody, e2f1.L antibody
Background
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.
Molecular Weight
70 kDa
Gene ID
1869
NCBI Accession
NP_005216
UniProt
Q01094
Pathways
p53 Signaling , Cell Division Cycle , Mitotic G1-G1/S Phases , DNA Replication , M Phase , Autophagy
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