ZAP70 antibody (N-Term)

Catalog No. ABIN926687

The Rabbit Polyclonal anti-ZAP70 antibody has been validated for WB. It is suitable to detect ZAP70 in samples from Human.

Quick Overview for ZAP70 antibody (N-Term) (ABIN926687)

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZAP70 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZAP70 Antibody

Binding Specificity: N-Term

Purification: Purified

Immunogen: ZAP70 antibody was raised in rabbit using the N terminal of ZAP70 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

ZAP70 Blocking Peptide, (ABIN5617066), is also available for use as a blocking control in assays to test for specificity of this ZAP70 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for ZAP70

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Alternative Name: ZAP70

Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. Synonyms: Polyclonal ZAP70 antibody, Anti-ZAP70 antibody, zeta-chain, TCR associated protein kinase 70kDa antibody, FLJ17670 antibody, FLJ17679 antibody, SRK antibody, STD antibody, TZK antibody, ZAP-70 antibody.

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway