SHP1 antibody (Middle Region)

Catalog No. ABIN926734

Product Details anti-SHP1 Antibody

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: PTPN6 antibody was raised in rabbit using the middle region of PTPN6 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

PTPN6 Blocking Peptide, catalog no. 33R-9938, is also available for use as a blocking control in assays to test for specificity of this PTPN6 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Alternative Name: PTPN6 (PTPN6 Products)

Synonyms: HCPH antibody, HPTP1C antibody, PTP-1C antibody, SH-PTP1 antibody, SHP-1 antibody, SHP-1L antibody, SHP1 antibody, DRPLA antibody, Hcph antibody, Ptp1C antibody, me antibody, motheaten antibody, Ptph6 antibody, Shp-1 antibody, fj22f05 antibody, wu:fj22f05 antibody, zgc:55501 antibody, ptpn6 antibody, protein tyrosine phosphatase, non-receptor type 6 antibody, protein tyrosine phosphatase, non-receptor type 6 L homeolog antibody, PTPN6 antibody, Ptpn6 antibody, ptpn6 antibody, ptpn6.L antibody

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Synonyms: Polyclonal PTPN6 antibody, Anti-PTPN6 antibody, protein tyrosine phosphatase, non-receptor type 6 antibody, HCP antibody, HCPH antibody, HPTP1C antibody, PTP-1C antibody, SH-PTP1 antibody, SHP-1 antibody, SHP-1L antibody, SHP1 antibody.

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling