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TDP1 antibody (Middle Region)

TDP1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN928939
  • Target See all TDP1 Antibodies
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 41
    • 15
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 35
    • 6
    • 1
    Rabbit
    Clonality
    • 38
    • 4
    Polyclonal
    Conjugate
    • 28
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    This TDP1 antibody is un-conjugated
    Application
    • 35
    • 21
    • 10
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Mouse (Murine)
    Purification
    Purified
    Immunogen
    Tdp1 antibody was raised in rabbit using the middle region of Tdp1 as the immunogen
    Top Product
    Discover our top product TDP1 Primary Antibody
  • Application Notes
    Optimal conditions should be determined by the investigator.
    Comment

    Tdp1 Blocking Peptide, catalog no. 33R-2766, is also available for use as a blocking control in assays to test for specificity of this Tdp1 antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
  • Target
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    Alternative Name
    Tdp1 (TDP1 Products)
    Synonyms
    2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, MLZ-501 antibody, SCAN1 antibody, tdp1 antibody, MGC83708 antibody, TDP1 antibody, F8M21.60 antibody, F8M21_60 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA Phosphodiesterase (Tdp1) antibody, tyrosyl-DNA phosphodiesterase 1 L homeolog antibody, tyrosyl-DNA phosphodiesterase-like protein antibody, TDP1 antibody, Tc00.1047053511191.10 antibody, Tdp1 antibody, tdp1.L antibody, tdp1 antibody, PTRG_11198 antibody, MCYG_02121 antibody, MGYG_03035 antibody
    Background
    Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate. Synonyms: Polyclonal Tdp1 antibody, Anti-Tdp1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, 2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, SCAN1 antibody.
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