Complement C2 antibody (N-Term)

Catalog No. ABIN951633

Product Details anti-Complement C2 Antibody

Target: Complement C2

Binding Specificity: AA 150-180, N-Term

Reactivity: Human, Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement C2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to Complement C2.

Cross-Reactivity (Details): Species reactivity (tested):Human and Hamster.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 150-180 amino acids from the N-terminal region of human C2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Complement C2

Target: Complement C2

Abstract: Complement C2 Products

Synonyms: CO2 antibody, complement C2 antibody, complement component 2 (within H-2S) antibody, C2 antibody

Background: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.Synonyms: C2, C3/C5 convertase, Complement component 2

Gene ID: 717

NCBI Accession: NP_000054