PEZ antibody, PTP36 antibody, C130080N23Rik antibody, OTTMUSG00000022087 antibody, protein tyrosine phosphatase, non-receptor type 14 antibody, PTPN14 antibody, Ptpn14 antibody
Background
The protein encoded by the PTPN14 gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.Synonyms: PTP36, PTPD2, Protein-tyrosine phosphatase pez, Tyrosine-protein phosphatase non-receptor type 14