IFNB1 antibody

Catalog No. ABIN964802

Product Details anti-IFNB1 Antibody

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Reactivity: Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: This product was protein A purified from monospecific antiserum by chomotography. This antibody is specific for swine IFN beta protein. A BLAST analysis was used to suggest cross-reactivity with IFN beta from swine, bat, bovine, horse, rhesus monkey, human, cat, chimpanzees, and ferret sources based on 100% homology with the immunizing sequence. Cross-reactivity with IFN beta from other sources has not been determined.

Characteristics: Type I interferons comprise a vast and growing group of IFN proteins. Homologous molecules to type I IFNs are found in many species, including all mammals, and some have been identified in birds, reptiles, amphibians and fish species. The mammalian types are designated IFN-alpha, IFN-beta, IFN-kappa, IFN-delta, IFN-epsilon, IFN-tau, IFN-omega, and IFN-zeta (also known as limitin). The IFN-beta proteins are produced in large quantities by fibroblasts. They have antiviral activity which is mainly involved in innate immune response. Two types of IFN-beta proteins have been described.

Purification: purified

Sterility: Sterile filtered

Immunogen: This protein A purified antibody was prepared from whole rabbit antiserum produced by repeated immunizations with a recombinant protein raised in yeast corresponding to 164 amino acids of the mature swine IFN beta protein.
Immunogen Type: RecombinantProtein

Isotype: IgG

Application Details

Application Notes: This protein A purified antibody is suitable for ELISA and Western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 19.5 kDa in size corresponding to swine IFN beta by western blotting in the appropriate cell lysate or extract.

Comment:

Gene Name: IFN beta

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Expiry Date: 12 months

Target Details for IFNB1

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Alternative Name: Interferon Beta (IFNB1 Products)

Synonyms: IFB antibody, IFF antibody, IFNB antibody, IFN-beta antibody, Ifb antibody, Ifnb antibody, IFNb antibody, interferon beta 1 antibody, interferon beta 1, fibroblast antibody, interferon, beta 1, fibroblast antibody, IFNB1 antibody, Ifnb1 antibody

Background: Type I interferons comprise a vast and growing group of IFN proteins. Homologous molecules to type I IFNs are found in many species, including all mammals, and some have been identified in birds, reptiles, amphibians and fish species. The mammalian types are designated IFN-alpha, IFN-beta, IFN-kappa, IFN-delta, IFN-epsilon, IFN-tau, IFN-omega, and IFN-zeta (also known as limitin). The IFN-beta proteins are produced in large quantities by fibroblasts. They have antiviral activity which is mainly involved in innate immune response. Two types of IFN-beta proteins have been described.
Synonyms: Interferon-beta, interferon-beta/ poIFN-beta, IFN

Gene ID: 445459

NCBI Accession: NP_001003923

UniProt: Q29412

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome