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RUNX1T1 antibody

RUNX1T1 Reactivity: Human IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN965546
  • Target See all RUNX1T1 Antibodies
    RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
    Reactivity
    • 36
    • 21
    • 11
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human
    Host
    • 33
    • 3
    Rabbit
    Clonality
    • 34
    • 2
    Polyclonal
    Conjugate
    • 25
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RUNX1T1 antibody is un-conjugated
    Application
    • 22
    • 11
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Purification
    Purified by antigen-specific affinity chromatography.
    Immunogen
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human AML1-MTG8(acute myelogenous leukemia 1 translocation 1 protein isoform MTG8c)
    Top Product
    Discover our top product RUNX1T1 Primary Antibody
  • Application Notes
    ELISA, Western blotting: 1µg/ml for 2hrs.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    This antibody is stored in PBS, 50% glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Martinez, Drescher, Riehle, Cullmann, Vornlocher, Ganser, Heil, Nordheim, Krauter, Heidenreich: "The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells." in: BMC cancer, Vol. 4, pp. 44, (2004) (PubMed).

  • Target
    RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
    Alternative Name
    AML1-MTG8 (RUNX1T1 Products)
    Synonyms
    MTG8 antibody, si:ch211-232j17.1 antibody, wu:fi14b07 antibody, zgc:154044 antibody, AML1T1 antibody, CBFA2T1 antibody, CDR antibody, ETO antibody, ZMYND2 antibody, Cbfa2t1h antibody, Cbfa2t1 antibody, runt-related transcription factor 1; translocated to, 1 (cyclin D-related) antibody, RUNX1 translocation partner 1 L homeolog antibody, RUNX1 translocation partner 1 antibody, runx1t1 antibody, runx1t1.L antibody, RUNX1T1 antibody, Runx1t1 antibody
    Background
    AML1-MTG8(acute myelogenous leukemia 1 translocation 1 protein isoform MTG8c) is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
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