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|Antigen||Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This Caspase 2 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-Caspase 2 AntibodyTarget Details Caspase 2 Application Details Handling Images
|Immunogen||Synthetic Peptide corresponding to 16 Amino Acid peptide from the amino-terminus of human Caspase-2.|
Target Details Caspase 2Product Details anti-Caspase 2 Antibody Application Details Handling Images back to top
|Alternative Name||Caspase-2 (CASP2 Antibody Abstract)|
|Background||Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis. Caspase-2 has two major isoforms, overexpression on the long form results in apoptosis while that of the short form suppresses cell death.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2|
|Research Area||Apoptosis/Necrosis, Cancer, Autophagy|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling Images back to top
Immunohistochemistry on Paraffin Sections (10 μg/mL). Immunocytochemistry. Western Blot (1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Images back to top
|Buffer||Phosphate Buffered Saline PBS, containing 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.|
ImagesProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling back to top