anti-Cow (Bovine) Caspase 8 antibody for Immunohistochemistry

Recommended Caspase 8 Antibody (supplied by: Log in to see )

Antigen
Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Antibodies
  • casp8-A
  • xCaspase-8
  • casp8
  • CASP8
  • CASP-8
  • FLICE
  • MACH
  • Mch5
  • ALPS2B
  • CAP4
  • Casp-8
  • MCH5
  • caspase-8
  • zgc:92075
  • caspase 8 L homeolog
  • death related ced-3/Nedd2-like protein
  • caspase 8
  • caspase-8
  • caspase-8-like
  • caspase 8, apoptosis-related cysteine peptidase
  • casp8.L
  • LOC661095
  • CASP8
  • LOC5563818
  • casp8
  • LOC100222284
  • Casp8
Epitope
C-Term
43
19
18
16
15
12
10
10
9
8
7
6
6
6
6
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus), Hamster, Dog (Canine), Cow (Bovine)
364
123
98
25
20
20
3
1
Host
Rabbit
279
118
10
2
Clonality
Polyclonal
Conjugate
This Caspase 8 antibody is un-conjugated
19
13
9
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
364
108
91
79
51
36
36
28
14
13
9
8
6
5
2
2
2
1
1
1
1
Supplier
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Catalog No. ABIN1585723
$ 327.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1077918 ICC IHC IP WB Rabbit IgG AA 25-175 Log in to see Polyclonal
1 ABIN2219209 IC IHC ELISA WB Rabbit IgG AA 25-175 Log in to see Polyclonal
1 ABIN4288164 IHC IHC (p) Rabbit Log in to see Polyclonal
1 ABIN1173794 IHC ELISA WB Biotin Rabbit IgG Log in to see Polyclonal
1 ABIN1173795 ICC IF IHC WB FITC Rabbit IgG Log in to see Polyclonal
1 ABIN2899511 ELISA IF/ICC IHC WB Rabbit AA 25-175 Log in to see Polyclonal

General

Antigen Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Antibodies
Epitope C-Term
(43), (19), (18), (16), (15), (12), (10), (10), (9), (8), (7), (6), (6), (6), (6), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus), Hamster, Dog (Canine), Cow (Bovine)
(364), (123), (98), (25), (20), (20), (3), (1)
Host Rabbit
(279), (118), (10), (2)
Clonality
Polyclonal
Conjugate This Caspase 8 antibody is un-conjugated
(19), (13), (9), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(364), (108), (91), (79), (51), (36), (36), (28), (14), (13), (9), (8), (6), (5), (2), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-Caspase 8 Antibody

Target Details Caspase 8 Application Details Handling References for anti-Caspase 8 antibody (ABIN1585723) Images
Cross-Reactivity Mouse (Murine), Rat (Rattus), Hamster, Dog (Canine), Cow (Bovine)
Purification Antibody was purified by Protein-A affinity chromatography.
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of rodent Caspase-8.

Target Details Caspase 8

Product Details anti-Caspase 8 Antibody Application Details Handling References for anti-Caspase 8 antibody (ABIN1585723) Images back to top
Antigen
Alternative Name Caspase-8 (CASP8 Antibody Abstract)
Background

Alternate Names: Caspase-8, CASP-8, ICE-like apoptotic protease 5, MORT1-assiociated CED-3 homolog, MACH, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, MCH5

Description: Caspase-8 is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Caspase-8 binding to the adapter molecule FADD recruits the complex to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) triggers caspase-8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. The enzyme then cleaves and activates caspase-3, caspase-4, caspase-6, caspase-7, caspase-9 and caspase-10. Granzyme B and CPP32 cleave caspase-8 at Asp 315 and Asp 330 respectively to generate the two active subunits.

UniProt Q14790
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades

Application Details

Product Details anti-Caspase 8 Antibody Target Details Caspase 8 Handling References for anti-Caspase 8 antibody (ABIN1585723) Images back to top
Application Notes E: 1:500-1:1,000, WB: 1:200-1:500, IHC: 1:200-1:500, IF: 1:100-1:500
Restrictions For Research Use only

Handling

Product Details anti-Caspase 8 Antibody Target Details Caspase 8 Application Details References for anti-Caspase 8 antibody (ABIN1585723) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Each vial contains 0.1 mg IgG in 0.1 mL (1 mg/mL) of PBS pH 7.4, 25 % glycerol, 1 mg/mL BSA with 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Handling Advice Minimize freeze-thaw cycles.
Storage -20 °C
Storage Comment Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Expiry Date 12 months

References for anti-Caspase 8 antibody (ABIN1585723)

Product Details anti-Caspase 8 Antibody Target Details Caspase 8 Application Details Handling Images back to top
Product cited in:

Soner, Aktug, Acikgoz, Duzagac, Guven, Ayla, Cal, Oktem: "Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol." in: International journal of molecular medicine, Vol. 34, Issue 5, pp. 1249-56, 2015