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|Antigen||CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Antibodies|
|Epitope||AA 1-376, N-Term Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CFLAR antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-CFLAR AntibodyTarget Details CFLAR Application Details Handling References for anti-CFLAR antibody (ABIN336100) Images
|Specificity||The antibody recognizes FLIP.|
|Characteristics||Synonyms: c-FLIP, CLARP, MRIT, CASH, FLAME-1, CASP8AP1, Usurpin, CASP8 and FADD-like apoptosisregulator, Caspase-eight-related protein, Inhibitor of FLICE, Cellular FLICE-like inhibitoryprotein, Caspase-like apoptosis regulatory protein, MACH-related inducer of toxicity,Caspase homolog, FADD-like antiapoptotic molecule 1|
|Purification||Affinity Chromatography on Protein G|
|Immunogen||Recombinant human FLIP (aa 1-376) purified from E. coli.|
Target Details CFLARProduct Details anti-CFLAR Antibody Application Details Handling References for anti-CFLAR antibody (ABIN336100) Images back to top
|Alternative Name||CFLAR / Casper / I-FLICE (CFLAR Antibody Abstract)|
|Background||FLIP, also known as CASP8 and FADD-like apoptosis regulator (CFLAR), contains two death effector domains (DEDs) and a caspase-like domain. FLIP may play a crucial role between cell survival and cell death pathway in mammalian cells and interacts with adapter protein FADD and Caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors DR3 (Death Receptor 3), TRAIL-R (TNF-related apoptosis-inducing ligand receptor) and TNFR1 (Tumor Necrosis Factor Receptor 1).Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP|
|Pathways||Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development|
Application DetailsProduct Details anti-CFLAR Antibody Target Details CFLAR Handling References for anti-CFLAR antibody (ABIN336100) Images back to top
ELISA. Western Blot (1/500-1/1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CFLAR Antibody Target Details CFLAR Application Details References for anti-CFLAR antibody (ABIN336100) Images back to top
|Buffer||PBS, pH 7.4, 0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for up to two weeks or (in aliquots) at -20 °C or -70 °Cfor longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
References for anti-CFLAR antibody (ABIN336100)Product Details anti-CFLAR Antibody Target Details CFLAR Application Details Handling Images back to top
Yu, Shi: "FLIP and the death effector domain family." in: Oncogene, Vol. 27, Issue 48, pp. 6216-27, 2008
Du, Guan, Yin, Zhong, Jevnikar: "IL-2-mediated apoptosis of kidney tubular epithelial cells is regulated by the caspase-8 inhibitor c-FLIP." in: Kidney international, Vol. 67, Issue 4, pp. 1397-409, 2005
ImagesProduct Details anti-CFLAR Antibody Target Details CFLAR Application Details Handling References for anti-CFLAR antibody (ABIN336100) back to top