anti-Bird (Avian) Cytochrome C antibody for Immunohistochemistry

Recommended Cytochrome C Antibody (supplied by: Log in to see )

Antigen
Cytochrome C, Somatic (CYCS) Antibodies
  • CYC
  • HCS
  • THC4
  • cyct
  • cyc
  • hcs
  • CYCS
  • cytc
  • CYCSA
  • CG17903
  • Cyt C
  • Cyt c
  • Cyt-c2
  • CytC-2
  • Cytc
  • Cytc-p
  • DC4
  • DMc01
  • Dmel\\CG17903
  • cyt c
  • cyt c-p
  • cyt-c-p
  • cyt-c2
  • cyt.c
  • cytochrome c
  • dc4
  • pDMc01
  • wu:fk52b01
  • zgc:86706
  • cytochrome c, somatic
  • cytochrome c, somatic S homeolog
  • Cytochrome c proximal
  • cytochrome c, somatic b
  • cytochrome c-like
  • cytochrome c
  • CYCS
  • cycs.S
  • cycs
  • Cycs
  • Cyt-c-p
  • cycsb
  • LOC100724240
  • CYC
  • LOC100847700
  • LOC101107954
  • LOC106829744
  • LOC106992390
Epitope
AA 93-104
26
18
16
12
11
8
6
5
5
4
4
3
3
3
2
2
1
1
1
1
Reactivity
Amphibian, Bird (Avian), Dog (Canine), Fruit Fly (Drosophila melanogaster), Horse (Equine), Human, Mouse (Murine), Rat (Rattus)
393
329
236
115
93
81
47
38
34
31
25
24
23
20
12
11
8
8
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
281
163
7
3
Clonality
Monoclonal
Conjugate
This Cytochrome C antibody is conjugated to Janelia Fluor® 646
20
12
12
7
7
7
6
6
5
5
5
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
354
176
147
123
114
73
49
42
40
26
23
13
6
5
4
4
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN5948580
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5948579 FACS IF IHC IHC (p) Janelia Fluor® 549 Mouse IgG2b kappa AA 93-104 Log in to see SPM389 0

General

Antigen Cytochrome C, Somatic (CYCS) Antibodies
Epitope AA 93-104
(26), (18), (16), (12), (11), (8), (6), (5), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity Amphibian, Bird (Avian), Dog (Canine), Fruit Fly (Drosophila melanogaster), Horse (Equine), Human, Mouse (Murine), Rat (Rattus)
(393), (329), (236), (115), (93), (81), (47), (38), (34), (31), (25), (24), (23), (20), (12), (11), (8), (8), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(281), (163), (7), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Cytochrome C antibody is conjugated to Janelia Fluor® 646
(20), (12), (12), (7), (7), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(354), (176), (147), (123), (114), (73), (49), (42), (40), (26), (23), (13), (6), (5), (4), (4), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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Product Details anti-Cytochrome C Antibody

Target Details Cytochrome C Application Details Handling Images
Specificity It recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C, a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Purification Protein A or G purified
Immunogen Synthetic peptides corresponding to amino acid 1-80, 81-104 and 66-104 of pigeon cytochrome c
Clone SPM389
Isotype IgG2b kappa
Plasmids, Primers & others

Target Details Cytochrome C

Product Details anti-Cytochrome C Antibody Application Details Handling Images back to top
Antigen
Alternative Name Cytochrome c (CYCS Antibody Abstract)
Background Gene Symbol: CYCS
Gene ID 54205
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only

Handling

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details Images back to top
Format Liquid
Buffer 50  mM Sodium Borate
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C in the dark.