General
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Antigen
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Perforin 1 (Pore Forming Protein) (PRF1) Antibodies
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Reactivity
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Human
Alternatives
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Host
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Mouse
Alternatives
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Clonality (Clone)
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Conjugate
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This Perforin 1 antibody is un-conjugated
Alternatives
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Application
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ELISA (Capture), ELISpot
Alternatives
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Supplier
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Log in to see
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Specificity
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Recognises Human Perforin, a 70 kDa protein.
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Cross-Reactivity (Details)
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Species reactivity (tested):Human.
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Purification
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Ion Exchange Chromatography
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Sterility
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0.22 μm filtered
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Immunogen
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Natural Human Perforin.
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Clone
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B-E48
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Isotype
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IgG2b
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Antigen
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Alternative Name
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Perforin 1 / PRF1 (PRF1 Antibody Abstract)
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Background
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Perforin is a potent cytolytic pore-forming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanisms in T-cell mediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis.Synonyms: Cytolysin, Lymphocyte pore-forming protein, PFN, PFP, Perforin-1, Pore forming protein
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Gene ID
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5551
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NCBI Accession
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NP_001076585
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UniProt
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P14222
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Pathways
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Apoptosis, Caspase Cascade in Apoptosis
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Application Notes
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Optimal working dilution should be determined by the investigator.
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Restrictions
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For Research Use only
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Concentration
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1.0 mg/mL
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Buffer
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Phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free
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Preservative
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Without preservative
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Storage
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4 °C
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Storage Comment
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Store the antibody undiluted at 2-8 °C.
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