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SARS-CoV-2 Mutations Tracker

Stay up to date re mutation specific antibodies, proteins, assays

SARS-CoV-2 Lineages

Fig. 1: Amino acid changes in the S proteins of different SARS-CoV-2 variants of concern and variants of interest. The RBD domain is highlighted orange. Download image as PDF!

Fig. 2: Amino acid changes in the N proteins of different SARS-CoV-2 variants of concern and variants of interest. The linker region is highlighted in orange.

B.1.1.529 Lineage / Omicron Lineage

Background B.1.1.529: The South African Institute of Infectious Diseases NICD said Thursday, Nov. 25, 2021, that 22 cases of the new variant B.1.1.529 (Omicron) have been detected in South Africa. The World Health Organization (WHO) is already investigating whether B.1.1.529 should be classified as a concern. Researchers spotted B.1.1.529 in genome-sequencing data from Botswana. The variant stood out because it contains more than 30 changes to the spike protein — the SARS-CoV-2 protein that recognizes host cells and is the main target of the body’s immune responses. Many of the changes have been found in variants such as Delta and Alpha and are linked to heightened infectivity and the ability to evade infection-blocking antibodies.

SARS-CoV-2 omicron lineage is made up of several sublineages, including BA.1 and BA.2, all of which are being monitored by WHO. As of 22.02 the BA.2 virus variant is considered a variant of concern. BA.2 is among the most common, with reported sequences increasing in recent weeks, relative to BA.1, though global circulation of all variants is currently declining. BA.2 differs from BA.1 in its genetic sequence, including some amino acid differences in the spike protein and other proteins. Studies have shown that BA.2 has a growth advantage over BA.1.

Mutations: A67V, H69del, V70del, T95I, G142del, V143del, Y144del, Y145D, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F

Mutations BA.2: T19I, L24DEL, P24DEL, P26DEL, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S,K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K

Proteins:

BA.1 Proteins - Omicron Variant

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7125933
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121375
Quantity 100 μg
Delivery 5 Days

BA.2 Proteins - Omicron Variant

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7121366
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7199315
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7125925
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7125926
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7072153
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7199332
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7072155
Quantity 100 μg
Delivery 21 to 31 Days

BA.2.75 - Omicron Proteins - Omicron Variant

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7194055
Quantity 100 μg
Delivery 5 Days

BA.3 Proteins - Omicron Variant

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7121372
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121370
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7199332
Quantity 200 μg
Delivery 5 Days

BA.4 Proteins - Omicron Variant

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7199356
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7125927
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121588
Quantity 100 μg
Delivery 2 to 3 Days

BA.5 Proteins - Omicron Variant

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7121590
Quantity 50 μg
Delivery 2 to 3 Days
Source HEK-293 Cells
Cat. No. ABIN7199356
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121589
Quantity 100 μg
Delivery 2 to 3 Days

Antibodies:

Neutralizing antibody CR3022 (ABIN6952467) and MM117 (ABIN7042145) are not affected by omciron mutations.

Click here for more detailed data and information regarding CR3022!

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Clone CR3022
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Validations
  • (10)
  • collections(14)
Quantity 200 μg
Clonality Monoclonal
Clone MM117
Isotype IgG1
Source Mouse
Cat. No. ABIN7042145
Validations
  • collections(3)
Quantity 100 μg
Clonality Monoclonal
Clone
Isotype IgG1
Source Mouse
Cat. No. ABIN6953169
Validations
  • collections(1)
Quantity 1 mg

References:

  • Alexander Wilhelm, Marek Widera, Katharina Grikscheit, Tuna Toptan, et al., Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies, preprint, https://doi.org/10.1101/2021.12.07.21267432
  • Heavily mutated coronavirus variant puts scientists on alert, Nature News, Internet: https://www.nature.com/articles/d41586-021-03552-w
  • https://covdb.stanford.edu/sierra/sars2/by-patterns/report/

B.1.1.7 Lineage / Alpha Lineage

Background B.1.1.7: Initially a UK lineage, associated with a variant of concern with N501Y, P681H and numerous other mutations. Evidence of having higher transmissibility than other lineage resulting in rapid growth in the UK and internationally.1

Mutations: N501Y, A570D, D614G, P681H, T716I ,S982A, D1118H, D3L (N protein), S235F (N protein), T1001I (orf1ab), A1708D (orf1ab), 2230T (orf1a), Q27 (orf8)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN6992374
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013273
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6992403
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013288
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6971310
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7036024
Quantity 100 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN6963742
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7013275
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7041706
Quantity 20 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN6972928
Quantity 100 μg
Delivery 12 to 14 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Clone CR3022
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Validations
  • (10)
  • collections(14)
Quantity 200 μg
Clonality Polyclonal
Clone
Isotype IgG
Source Rabbit
Cat. No. ABIN6952962
Validations
  • collections(8)
Quantity 0.1 mg
Clonality Chimeric
Clone AM122
Isotype IgG1
Source Human
Cat. No. ABIN6953206
Validations
  • collections(5)
Quantity 100 μg
Clonality Chimeric
Clone CR3022
Isotype IgG kappa
Source Rabbit
Cat. No. ABIN6952547
Validations
  • (8)
  • collections(3)
Quantity 200 μg
Clonality Monoclonal
Clone SP185
Isotype IgG kappa
Source Rabbit
Cat. No. ABIN6990085
Validations
  • collections(1)
Quantity 0.1 mg
Clonality Monoclonal
Clone
Isotype IgG1
Source Mouse
Cat. No. ABIN6953169
Validations
  • collections(1)
Quantity 1 mg
Clonality Polyclonal
Clone
Isotype IgG
Source Rabbit
Cat. No. ABIN6992311
Validations
Quantity 0.1 mg

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

References:

  • Pengfei Wang, Lihong Liu, Sho Iketani, Yang Luo et al. Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization. bioRxiv preprint posted January 26, 2021. ; https://doi.org/10.1101/2021.01.25.428137doi.
  • Reuschl, A.-K., Thome, L. G., Zuliani-Alvarez, L., et al. Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. bioRxiv preprint posted January 24, 2021. ; https://dx.doi.org/10.1101%2F2021.01.24.427991.
  • Xiaoying Shen, Haili Tang, Charlene McDanal, et al. SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines. https://doi.org/10.1016/j.chom.2021.03.002.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013
  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939

B.1.351 Lineage / Beta Lineage

Background B.1.351: A lineage first identified in South Africa and defined by new variant of concern 501Y.V2

Mutations: K417N, A570D, D614G, P681H, T716I, S982A, D1118H, L18F, D215G, K417K, E484K, N501Y, A701V, P71L (E protein), T205I (N protein), K1655N (orf1a)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN6992376
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013274
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013278
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6992404
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013287
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6992378
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7200339
Quantity 100 μg
Delivery 9 to 10 Days
Source HEK-293 Cells
Cat. No. ABIN7200341
Quantity 100 μg
Delivery 9 to 10 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7200331
Quantity 100 μg
Delivery 9 to 10 Days
Source HEK-293 Cells
Cat. No. ABIN6971311
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN6992400
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7036025
Quantity 100 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN6963740
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7041707
Quantity 20 μg
Delivery 11 to 13 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7041817
Quantity 20 μg
Delivery 11 to 13 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7036018
Quantity 100 μg
Delivery 11 to 13 Days
Source Escherichia coli (E. coli)
Cat. No. ABIN7036017
Quantity 100 μg
Delivery 11 to 13 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Clone CR3022
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Validations
  • (10)
  • collections(14)
Quantity 200 μg
Clonality Polyclonal
Clone
Isotype IgG
Source Rabbit
Cat. No. ABIN6952962
Validations
  • collections(8)
Quantity 0.1 mg
Clonality Chimeric
Clone AM122
Isotype IgG1
Source Human
Cat. No. ABIN6953206
Validations
  • collections(5)
Quantity 100 μg
Clonality Chimeric
Clone CR3022
Isotype IgG kappa
Source Rabbit
Cat. No. ABIN6952547
Validations
  • (8)
  • collections(3)
Quantity 200 μg
Clonality Monoclonal
Clone
Isotype IgG1
Source Mouse
Cat. No. ABIN6953169
Validations
  • collections(1)
Quantity 1 mg

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B1.167.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

References:

  • Pengfei Wang, Lihong Liu, Sho Iketani, Yang Luo et al. Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization. bioRxiv preprint posted January 26, 2021. ; https://doi.org/10.1101/2021.01.25.428137doi.
  • Mary Hongying Cheng, James M Krieger, Burak Kaynak, et al. Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment. doi: https://doi.org/10.1101/2021.01.10.426143.
  • Hoffmann, M., Arora, P., Groß, R., et al. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. To appear in Cell. DOI: https://doi.org/10.1016/j.cell.2021.03.036.
  • Venkata Viswanadh Edara, Carson Norwood, Katharine Floyd, et al. Infection and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant. Cell Host & Microbe, Mar 21, 2021. https://doi.org/10.1016/j.chom.2021.03.009.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013
  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939

B.1.429 Lineage / Epsilon Lineage

Background B.1.429: A lineage predominantly circulating in California but with exports to other countries.1

Mutations: L452R, W152C, D5584Y (orf1ab), T205I (N protein)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7013307
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013308
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7036022
Quantity 100 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN6972926
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7041701
Quantity 100 μg
Delivery 11 to 13 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Clone CR3022
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Validations
  • (10)
  • collections(14)
Quantity 200 μg
Clonality Chimeric
Clone AM122
Isotype IgG1
Source Human
Cat. No. ABIN6953206
Validations
  • collections(5)
Quantity 100 μg
Clonality Chimeric
Clone CR3022
Isotype IgG kappa
Source Rabbit
Cat. No. ABIN6952547
Validations
  • (8)
  • collections(3)
Quantity 200 μg

References:

  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013
  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939
  • McCallum M, Bassi J, Marco A, Chen A, Walls AC, Iulio JD, Tortorici MA, Navarro MJ, Silacci-Fregni C, Saliba C, Agostini M, Pinto D, Culap K, Bianchi S, Jaconi S, Cameroni E, Bowen JE, Tilles SW, Pizzuto MS, Guastalla SB, Bona G, Pellanda AF, Garzoni C, Van Voorhis WC, Rosen LE, Snell G, Telenti A, Virgin HW, Piccoli L, Corti D, Veesler D. SARS-CoV-2 immune evasion by variant B.1.427/B.1.429. bioRxiv [Preprint]. 2021 Apr 1:2021.03.31.437925. doi: 10.1101/2021.03.31.437925. PMID: 33821281; PMCID: PMC8020983.

B.1.526 Lineage / Iota Lineage

Background B.1.526: The variant that Ho’s team identified in New York, also known as B.1.526, carries a notorious mutation called E484K that has been found in variants identified in South Africa and Brazil. Studies by multiple labs have shown that the E484K change — which is in a portion of the coronavirus spike protein that recognizes host cells — weakens the potency of antibodies that can ordinarily disable the virus.7

Mutations: T95I, D253G, L5F, D253G, E484K, D614G, A701V with a smaller fraction having S477N instead of E484K.1

Proteins:

- Products under development. Get in touch! -

References:

  • Annavajhala, M. K., Mohri, H., Zucker, J. E., et al. A Novel SARS-CoV-2 Variant of Concern, B.1.526, Identified in New York. doi: https://doi.org/10.1101/2021.02.23.21252259.

B.1.617.1 Lineage / Kappa Lineage

Mutations: E484Q, L452R

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7013328
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013125
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013330
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013132
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6992290
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7013325
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013118
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013117
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6976302
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7013111
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7041802
Quantity 20 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN7041698
Quantity 100 μg
Delivery 11 to 13 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7041816
Quantity 20 μg
Delivery 11 to 13 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7041833
Quantity 100 μg
Delivery 11 to 13 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Clone CR3022
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Validations
  • (10)
  • collections(14)
Quantity 200 μg
Clonality Chimeric
Clone CR3022
Isotype IgG kappa
Source Rabbit
Cat. No. ABIN6952547
Validations
  • (8)
  • collections(3)
Quantity 200 μg

References:

B.1.617.2 Lineage / Delta Lineage

Background B.1.617.2: A lineage circulating with variants of biological significance S:P681R and S:L452R, first detected in India and international cases with travel history from India.8

Mutations: S:P681R and S:L452R

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7121376
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013339
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013124
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013356
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013337
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7012937
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013334
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013122
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013121
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7200444
Quantity 20 μg
Delivery 9 to 10 Days
Source HEK-293 Cells
Cat. No. ABIN7121374
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6999328
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7013110
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7199270
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121329
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013234
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013351
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013114
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121354
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7200436
Quantity 100 μg
Delivery 9 to 10 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B1.167.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

Product
Clonality
Isotype
Source
Cat. No.
Quantity
Datasheet
Clonality Monoclonal
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Quantity 200 μg
Clonality Monoclonal
Isotype IgG1
Source Mouse
Cat. No. ABIN7042145
Quantity 100 μg
Clonality Monoclonal
Isotype IgG1
Source Mouse
Cat. No. ABIN6953169
Quantity 1 mg

References:

  • Cherian S. et al. : "SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India" Microorganisms. 2021 doi: 10.3390/microorganisms9071542

B.1.621 Lineage / Mu Lineage

Mutations: T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN7199274
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121333
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7199300
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7199286
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7121336
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013133
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7041796
Quantity 100 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN7041801
Quantity 100 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN7041805
Quantity 100 μg
Delivery 11 to 13 Days

Antibodies:

References:

- will be added -

B.1.640.2 Variant

Background B.1.640.2: The B.1.640.2 variant was first identified in October and uploaded to Gisaid, a database for disease variants, on Nov. 4. Abdi Mahmud, a Covid incident manager with the W.H.O., told reporters in Geneva on Tuesday that the variant had been on the agency’s radar since November, but added that it did not appear to have spread widely over the past two months.1

Mutations: 46 mutations and 37 deletions resulting in 30 amino acid substitutions and 12 deletions. Fourteen amino acid substitutions, including N501Y and E484K, and 9 deletions are located in the spike protein.

Proteins:

- will be added -

References:

  • Philippe Colson, Jérémy Delerce, Emilie Burel, Jordan Dahan, Agnès Jouffret, et al., Emergence in Southern France of a new SARS-CoV-2 variant of probably Cameroonian origin harbouring both substitutions N501Y and E484K in the spike protein, Preprint, https://www.medrxiv.org/content/10.1101/2021.12.24.21268174v1
  • (1) https://www.nytimes.com/2022/01/05/world/covid-variant-france.html

P.1 Lineage / Gamma Lineage

Background P.1: A lineage first identified in Brazil with variants of biological significance E484K, N501Y and K417T, described in a recent virological post: here. P.1 lineage is an alias of lineage B.1.1.28.1.1

Mutations: V1176F, L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, P80R (N protein), G174C (orf3a), E92K (orf8)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN6992375
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6992361
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6992402
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013289
Quantity 200 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7200340
Quantity 100 μg
Delivery 9 to 10 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7200332
Quantity 100 μg
Delivery 9 to 10 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7200326
Quantity 100 μg
Delivery 9 to 10 Days
Source HEK-293 Cells
Cat. No. ABIN6992401
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN6964443
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7013280
Quantity 50 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7013281
Quantity 100 μg
Delivery 5 Days
Source HEK-293 Cells
Cat. No. ABIN7200440
Quantity 100 μg
Delivery 9 to 10 Days
Source HEK-293 Cells
Cat. No. ABIN7036033
Quantity 100 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN7036026
Quantity 100 μg
Delivery 11 to 13 Days
Source HEK-293 Cells
Cat. No. ABIN7036030
Quantity 100 μg
Delivery 11 to 13 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Clone CR3022
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Validations
  • (10)
  • collections(14)
Quantity 200 μg
Clonality Polyclonal
Clone
Isotype IgG
Source Rabbit
Cat. No. ABIN6952962
Validations
  • collections(8)
Quantity 0.1 mg
Clonality Chimeric
Clone AM122
Isotype IgG1
Source Human
Cat. No. ABIN6953206
Validations
  • collections(5)
Quantity 100 μg
Clonality Chimeric
Clone CR3022
Isotype IgG kappa
Source Rabbit
Cat. No. ABIN6952547
Validations
  • (8)
  • collections(3)
Quantity 200 μg
Clonality Monoclonal
Clone
Isotype IgG1
Source Mouse
Cat. No. ABIN6953169
Validations
  • collections(1)
Quantity 1 mg

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B1.167.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

References:

  • Toovey OTR, Harvey KN, Bird PW, Tang JWW. Introduction of Brazilian SARS-CoV-2 484K.V2 related variants into the UK [published online ahead of print, 2021 Feb 3]. J Infect. 2021;S0163-4453(21)00047-5. doi:10.1016/j.jinf.2021.01.025
  • Wilfredo F. G.-B., Evan C. Lam, Kerri St. D., Adam D. N. Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. doi: https://doi.org/10.1101/2021.02.14.21251704.
  • Hoffmann, M., Arora, P., Groß, R., et al. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. To appear in Cell. DOI: https://doi.org/10.1016/j.cell.2021.03.036.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013

A.23.1 Lineage

Background A.23.1: International lineage with variants of biological significance F157L, V367F, Q613H and P681R, described fully in the preprent: Bugembe et al 2021. Q613H is predicted to be functionally equivalent to the D614G mutation that arose early in 2020.1

Mutations: F157L, V367F, Q613H and P681R

Proteins:

- Products under development. Get in touch! -

References:

  • Bugembe, D. L., Phan, My V.T., Ssewanyana, I., et al. A SARS-CoV-2 lineage A variant (A.23.1) with altered spike has emerged and is dominating the current Uganda epidemic. medRxiv 2021.02.08.21251393; doi: https://doi.org/10.1101/2021.02.08.21251393

B.1.2 Lineage

Background B.1.2: Independent genomic surveillance programs based in New Mexico and Louisiana contemporaneously detected the rapid rise of numerous clade 20G (lineage B.1.2) infections carrying a Q677P substitution in S. The variant was first detected in the US on October 23, yet between 01 Dec 2020 and 19 Jan 2021 it rose to represent 27.8% and 11.3% of all SARS-CoV-2 genomes sequenced from Louisiana and New Mexico, respectively.6

Mutations: Q677P

Proteins:

- Products under development. Get in touch! -

References:

  • Hodcroft, E. B., Domman, D. B., Snyder, D. J. Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. medRxiv preprint on February 14, 2021. doi: https://doi.org/10.1101/2021.02.12.21251658

Wild Type Protein

We offer a high quality recombinant SARS-CoV-2 wild type protein. Click on the link to find more details.

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN6952670
Quantity 100 μg
Delivery 6 to 7 Days

B.1.525 Lineage / Eta Lineage

Background B.1.525: International lineage with variants of biological significance E484K, Q677H, F888L and a similar suite of deletions to B.1.1.7.1

Mutations: E484K, Q677H, F888L and a similar suite of deletions to B.1.1.7., Q52R, L21F (E protein), I82T (E protein), L471F (orf1ab)1

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
Source HEK-293 Cells
Cat. No. ABIN6972924
Quantity 100 μg
Delivery 6 to 7 Days
Source HEK-293 Cells
Cat. No. ABIN7041702
Quantity 100 μg
Delivery 11 to 13 Days
Source Baculovirus infected Insect Cells
Cat. No. ABIN7041830
Quantity 100 μg
Delivery 11 to 13 Days
Source Escherichia coli (E. coli)
Cat. No. ABIN7036010
Quantity 100 μg
Delivery 11 to 13 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Clone CR3022
Isotype IgG1 kappa
Source Human
Cat. No. ABIN6952546
Validations
  • (10)
  • collections(14)
Quantity 200 μg
Clonality Chimeric
Clone CR3022
Isotype IgG kappa
Source Rabbit
Cat. No. ABIN6952547
Validations
  • (8)
  • collections(3)
Quantity 200 μg

CR3022 antibodies: bind to epitope residues in the RBD that are not mutated2,3,4,5

References:

  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939

CR3022 not affected by B.1.1.529 / omicron Variant Mutations

One of the looming questions regarding newly emerging variants of SARS-CoV-2 is, whether existing antibody based assays and pharmaceuticals remain useable. In collaboration with Nanotemper we measured the affinity of our S protein RBD antibody CR3022 (ABIN6952546) to the canonical trimeric SARS-CoV-2 S protein and those of the variants of concern B.1.1.7 / alpha, B.1.351 / beta, B.1.617.2 / delta, B.1.617.1 / kappa and P.1 / gamma by microscale thermophoresis (MST). In a second iteration we acknowledged the dominant B.1.1.529 / omicron variant and extended the antibody selection with neutralizing antibodies MM43 (ABIN7036075) and MM117 (ABIN7042145). Discover the results down below.

Click here for more detailed data and information regarding CR3022!

Get our free SARS-CoV-2 Handbook now!

49 Pages Handbook * Free Download * Antibodies and Proteins * SARS-CoV-2 Lineages * Mutations & Implications for NAbs

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General References

  • (1) https://cov-lineages.org/global_report.html
  • (2) Barnes CO et al. SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature (2020). doi:10.1038/s41586-020-2852-1
  • (3) Cheng MH et al. Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment. bioRxiv 2021.01.10.426143 (2021). doi:10.1101/2021.01.10.426143
  • (4) Garcia-Beltran WF et al. Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. medRxiv 2021.02.14.21251704 (2021). doi:10.1101/2021.02.14.21251704
  • (5) Yuan M et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science 368, 630–633 (2020).
  • (6) Hodcroft, E. B., Domman, D. B., Snyder, D. J. Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. medRxiv preprint on February 14, 2021. doi: https://doi.org/10.1101/2021.02.12.21251658
  • (7) https://www.nature.com/articles/d41586-021-00564-4
  • (8) https://www.nature.com/articles/d41586-021-01059-y
Barnes, Jette, Abernathy, Dam, Esswein, Gristick, Malyutin, Sharaf, Huey-Tubman, Lee, Robbiani, Nussenzweig, West, Bjorkman: "SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies." in: Nature, Vol. 588, Issue 7839, pp. 682-687, (2021) (PubMed).

Garcia-Beltran, Lam, St Denis, Nitido, Garcia, Hauser, Feldman, Pavlovic, Gregory, Poznansky, Sigal, Schmidt, Iafrate, Naranbhai, Balazs: "Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity." in: medRxiv : the preprint server for health sciences, (2021) (PubMed).

Yuan, Wu, Zhu, Lee, So, Lv, Mok, Wilson: "A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV." in: Science (New York, N.Y.), (2020) (PubMed).

Hodcroft, Domman, Snyder, Oguntuyo, Van Diest, Densmore, Schwalm, Femling, Carroll, Scott, Whyte, Edwards, Hull, Kevil, Vanchiere, Lee, Dinwiddie, Cooper, Kamil: "Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677." in: medRxiv : the preprint server for health sciences, (2021) (PubMed).

Stefan Pellenz
Dr. Stefan Pellenz, PhD
Product Manager at antibodies-online.com

Goal-oriented, time line driven scientist, proficiently trained in different academic institutions in Germany, France and the USA. Experienced in the life sciences e-commerce environment with a focus on product development and customer relation management.

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