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SARS-CoV-2 Mutations Tracker

Stay up to date re mutation specific antibodies, proteins, assays

SARS-CoV-2 Lineages

Fig. 1: Amino acid changes in the spike region of the genomes mapped to the spike protein sequences structure. Comparison of Mutations in the viral spike. RBD region is highlighted (orange).

B.1.1.7 Lineage / Alpha Lineage

Background B.1.1.7: Initially a UK lineage, associated with a variant of concern with N501Y, P681H and numerous other mutations. Evidence of having higher transmissibility than other lineage resulting in rapid growth in the UK and internationally.1

Mutations: N501Y, A570D, D614G, P681H, T716I ,S982A, D1118H, D3L (N protein), S235F (N protein), T1001I (orf1ab), A1708D (orf1ab), 2230T (orf1a), Q27 (orf8)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6963742
Quantity100 μg
Delivery6 to 7 Days
SourceHEK-293 Cells
Cat. No.ABIN6971314
Quantity100 μg
Delivery5 Days

Multiplex ELISAs:

Product
Cat. No.
Quantity
Delivery
Datasheet
Cat. No.ABIN6972933
Quantity96 tests
Delivery7 to 8 Days
Cat. No.ABIN6972931
Quantity96 tests
Delivery7 to 8 Days
Cat. No.ABIN6972932
Quantity96 tests
Delivery7 to 8 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
ClonalityMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Cat. No.ABIN6952546
Validations
  • (9)
  • collections(13)
Quantity200 μg
ClonalityChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Cat. No.ABIN6952547
Validations
  • (7)
  • collections(3)
Quantity200 μg
ClonalityChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Cat. No.ABIN6953206
Validations
  • collections(5)
Quantity100 μg

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

Product
Clonality
Isotype
Source
Cat. No.
Quantity
Datasheet
ClonalityMonoclonal
IsotypeIgG1
SourceMouse
Cat. No.ABIN6953169
Quantity1 mg

References:

  • Pengfei Wang, Lihong Liu, Sho Iketani, Yang Luo et al. Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization. bioRxiv preprint posted January 26, 2021. ; https://doi.org/10.1101/2021.01.25.428137doi.
  • Reuschl, A.-K., Thome, L. G., Zuliani-Alvarez, L., et al. Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. bioRxiv preprint posted January 24, 2021. ; https://dx.doi.org/10.1101%2F2021.01.24.427991.
  • Xiaoying Shen, Haili Tang, Charlene McDanal, et al. SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines. https://doi.org/10.1016/j.chom.2021.03.002.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013
  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939

B.1.351 Lineage / Beta Lineage

Background B.1.351: A lineage first identified in South Africa and defined by new variant of concern 501Y.V2

Mutations: K417N, A570D, D614G, P681H, T716I, S982A, D1118H, L18F, D215G, K417K, E484K, N501Y, A701V, P71L (E protein), T205I (N protein), K1655N (orf1a)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6963740
Quantity100 μg
Delivery6 to 7 Days

Multiplex ELISAs:

Product
Cat. No.
Quantity
Delivery
Cat. No.ABIN6972933
Quantity96 tests
Delivery7 to 8 Days
Cat. No.ABIN6972931
Quantity96 tests
Delivery7 to 8 Days
Cat. No.ABIN6972932
Quantity96 tests
Delivery7 to 8 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
ClonalityMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Cat. No.ABIN6952546
Validations
  • (9)
  • collections(13)
Quantity200 μg
ClonalityChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Cat. No.ABIN6952547
Validations
  • (7)
  • collections(3)
Quantity200 μg
ClonalityChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Cat. No.ABIN6953206
Validations
  • collections(5)
Quantity100 μg

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B1.167.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

Product
Clonality
Isotype
Source
Cat. No.
Quantity
Datasheet
ClonalityMonoclonal
IsotypeIgG1
SourceMouse
Cat. No.ABIN6953169
Quantity1 mg

References:

  • Pengfei Wang, Lihong Liu, Sho Iketani, Yang Luo et al. Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization. bioRxiv preprint posted January 26, 2021. ; https://doi.org/10.1101/2021.01.25.428137doi.
  • Mary Hongying Cheng, James M Krieger, Burak Kaynak, et al. Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment. doi: https://doi.org/10.1101/2021.01.10.426143.
  • Hoffmann, M., Arora, P., Groß, R., et al. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. To appear in Cell. DOI: https://doi.org/10.1016/j.cell.2021.03.036.
  • Venkata Viswanadh Edara, Carson Norwood, Katharine Floyd, et al. Infection and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant. Cell Host & Microbe, Mar 21, 2021. https://doi.org/10.1016/j.chom.2021.03.009.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013
  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939

B.1.429 Lineage / Epsilon Lineage

Background B.1.429: A lineage predominantly circulating in California but with exports to other countries.1

Mutations: L452R, W152C, D5584Y (orf1ab), T205I (N protein)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6972926
Quantity100 μg
Delivery6 to 7 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
ClonalityMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Cat. No.ABIN6952546
Validations
  • (9)
  • collections(13)
Quantity200 μg
ClonalityChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Cat. No.ABIN6952547
Validations
  • (7)
  • collections(3)
Quantity200 μg
ClonalityChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Cat. No.ABIN6953206
Validations
  • collections(5)
Quantity100 μg

References:

  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013
  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939
  • McCallum M, Bassi J, Marco A, Chen A, Walls AC, Iulio JD, Tortorici MA, Navarro MJ, Silacci-Fregni C, Saliba C, Agostini M, Pinto D, Culap K, Bianchi S, Jaconi S, Cameroni E, Bowen JE, Tilles SW, Pizzuto MS, Guastalla SB, Bona G, Pellanda AF, Garzoni C, Van Voorhis WC, Rosen LE, Snell G, Telenti A, Virgin HW, Piccoli L, Corti D, Veesler D. SARS-CoV-2 immune evasion by variant B.1.427/B.1.429. bioRxiv [Preprint]. 2021 Apr 1:2021.03.31.437925. doi: 10.1101/2021.03.31.437925. PMID: 33821281; PMCID: PMC8020983.

B.1.526 Lineage / Iota Lineage

Background B.1.526: The variant that Ho’s team identified in New York, also known as B.1.526, carries a notorious mutation called E484K that has been found in variants identified in South Africa and Brazil. Studies by multiple labs have shown that the E484K change — which is in a portion of the coronavirus spike protein that recognizes host cells — weakens the potency of antibodies that can ordinarily disable the virus.7

Mutations: T95I, D253G, L5F, D253G, E484K, D614G, A701V with a smaller fraction having S477N instead of E484K.1

Proteins:

- Products under development. Get in touch! -

References:

  • Annavajhala, M. K., Mohri, H., Zucker, J. E., et al. A Novel SARS-CoV-2 Variant of Concern, B.1.526, Identified in New York. doi: https://doi.org/10.1101/2021.02.23.21252259.

B.1.617.1 Lineage / Kappa Lineage

Mutations: E484Q, L452R

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6992290
Quantity100 μg
Delivery6 to 7 Days
SourceHEK-293 Cells
Cat. No.ABIN6976302
Quantity100 μg
Delivery6 to 7 Days

References:

B.1.617.2 Lineage / Delta Lineage

Background B.1.617.2: A lineage circulating with variants of biological significance S:P681R and S:L452R, first detected in India and international cases with travel history from India.8

Mutations: S:P681R and S:L452R

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6999328
Quantity100 μg
Delivery6 to 7 Days
SourceHEK-293 Cells
Cat. No.ABIN7013114
Quantity100 μg
Delivery5 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
ClonalityMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Cat. No.ABIN6952546
Validations
  • (9)
  • collections(13)
Quantity200 μg
ClonalityChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Cat. No.ABIN6952547
Validations
  • (7)
  • collections(3)
Quantity200 μg
ClonalityChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Cat. No.ABIN6953206
Validations
  • collections(5)
Quantity100 μg

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B1.167.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

Product
Clonality
Isotype
Source
Cat. No.
Quantity
Datasheet
ClonalityMonoclonal
IsotypeIgG1
SourceMouse
Cat. No.ABIN6953169
Quantity1 mg

References:

  • Cherian S. et al. : "SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India" Microorganisms. 2021 doi: 10.3390/microorganisms9071542

B.1.621 Lineage / Mu Lineage

Mutations: T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN7013133
Quantity100 μg
Delivery30 to 35 Days

References:

- will be added -

P.1 Lineage / Gamma Lineage

Background P.1: A lineage first identified in Brazil with variants of biological significance E484K, N501Y and K417T, described in a recent virological post: here. P.1 lineage is an alias of lineage B.1.1.28.1.1

Mutations: V1176F, L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, P80R (N protein), G174C (orf3a), E92K (orf8)

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6964443
Quantity100 μg
Delivery6 to 7 Days

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251, B.1.617.1+2 and P.1 Mutations! Click to see detailed data.

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
ClonalityMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Cat. No.ABIN6952546
Validations
  • (9)
  • collections(13)
Quantity200 μg
ClonalityChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Cat. No.ABIN6952547
Validations
  • (7)
  • collections(3)
Quantity200 μg
ClonalityChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Cat. No.ABIN6953206
Validations
  • collections(5)
Quantity100 μg

N-protein antibodies ABIN6953169 and ABIN6953170 form an antibody pair and are specific for SARS-CoV-2 Nucleocapsid Protein. The pair detects Alpha (B.1.1.7), Beta (B.1.351), Delta (B1.167.2) and Gamma (P.1/P.2) variants of SARS-CoV-2.

Product
Clonality
Isotype
Source
Cat. No.
Quantity
Datasheet
ClonalityMonoclonal
IsotypeIgG1
SourceMouse
Cat. No.ABIN6953169
Quantity1 mg

References:

  • Toovey OTR, Harvey KN, Bird PW, Tang JWW. Introduction of Brazilian SARS-CoV-2 484K.V2 related variants into the UK [published online ahead of print, 2021 Feb 3]. J Infect. 2021;S0163-4453(21)00047-5. doi:10.1016/j.jinf.2021.01.025
  • Wilfredo F. G.-B., Evan C. Lam, Kerri St. D., Adam D. N. Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. doi: https://doi.org/10.1101/2021.02.14.21251704.
  • Hoffmann, M., Arora, P., Groß, R., et al. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. To appear in Cell. DOI: https://doi.org/10.1016/j.cell.2021.03.036.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013

A.23.1 Lineage

Background A.23.1: International lineage with variants of biological significance F157L, V367F, Q613H and P681R, described fully in the preprent: Bugembe et al 2021. Q613H is predicted to be functionally equivalent to the D614G mutation that arose early in 2020.1

Mutations: F157L, V367F, Q613H and P681R

Proteins:

- Products under development. Get in touch! -

References:

  • Bugembe, D. L., Phan, My V.T., Ssewanyana, I., et al. A SARS-CoV-2 lineage A variant (A.23.1) with altered spike has emerged and is dominating the current Uganda epidemic. medRxiv 2021.02.08.21251393; doi: https://doi.org/10.1101/2021.02.08.21251393

B.1.2 Lineage

Background B.1.2: Independent genomic surveillance programs based in New Mexico and Louisiana contemporaneously detected the rapid rise of numerous clade 20G (lineage B.1.2) infections carrying a Q677P substitution in S. The variant was first detected in the US on October 23, yet between 01 Dec 2020 and 19 Jan 2021 it rose to represent 27.8% and 11.3% of all SARS-CoV-2 genomes sequenced from Louisiana and New Mexico, respectively.6

Mutations: Q677P

Proteins:

- Products under development. Get in touch! -

References:

  • Hodcroft, E. B., Domman, D. B., Snyder, D. J. Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. medRxiv preprint on February 14, 2021. doi: https://doi.org/10.1101/2021.02.12.21251658

Wild Type Protein

We offer a high quality recombinant SARS-CoV-2 wild type protein. Click on the link to find more details.

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6952670
Quantity100 μg
Delivery6 to 7 Days

B.1.525 Lineage / Eta Lineage

Background B.1.525: International lineage with variants of biological significance E484K, Q677H, F888L and a similar suite of deletions to B.1.1.7.1

Mutations: E484K, Q677H, F888L and a similar suite of deletions to B.1.1.7., Q52R, L21F (E protein), I82T (E protein), L471F (orf1ab)1

Proteins:

Product
Source
Cat. No.
Quantity
Delivery
Datasheet
SourceHEK-293 Cells
Cat. No.ABIN6972924
Quantity100 μg
Delivery6 to 7 Days

CR3022 antibodies: bind to epitope residues in the RBD that are not mutated2,3,4,5

Product
Clonality
Clone
Isotype
Source
Cat. No.
Validations
Quantity
Datasheet
ClonalityMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Cat. No.ABIN6952546
Validations
  • (9)
  • collections(13)
Quantity200 μg
ClonalityChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Cat. No.ABIN6952547
Validations
  • (7)
  • collections(3)
Quantity200 μg

References:

  • Emily Engelhart, Randolph Lopez, Ryan Emerson, Charles Lin, Colleen Shikany, Daniel Guion, Mary Kelley, David Younger. Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants. Preprint. bioRxiv 2021.04.27.440939; doi: https://doi.org/10.1101/2021.04.27.440939

CR3022 not affected by B.1.1.7, B.1.251, B.1.617.1, B.1.617.2 and P.1 Mutations

One of the looming questions regarding newly emerging variants of SARS-CoV-2 such as the variants of concern B.1.1.7, B.1.351, B.1.617.2 and P.1. is, whether existing antibody based assays and pharmaceuticals remain useable. In collaboration with NanoTemper Technologies we measured the affinity of our S protein RBD antibody CR3022 (ABIN6952546) to the canonical trimeric SARS-CoV-2 S protein and those of the variants of concern B.1.1.7, B.1.351, B.1.617.2, B.1.617.2 and P.1. by microscale thermophoresis (MST). These measurements will be extended to additional antibodies and protein variants in the near future.

Click here for more detailed data and information regarding CR3022!

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49 Pages Handbook * Free Download * Antibodies and Proteins * SARS-CoV-2 Lineages * Mutations & Implications for NAbs

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General References

  • (1) https://cov-lineages.org/global_report.html
  • (2) Barnes CO et al. SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature (2020). doi:10.1038/s41586-020-2852-1
  • (3) Cheng MH et al. Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment. bioRxiv 2021.01.10.426143 (2021). doi:10.1101/2021.01.10.426143
  • (4) Garcia-Beltran WF et al. Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. medRxiv 2021.02.14.21251704 (2021). doi:10.1101/2021.02.14.21251704
  • (5) Yuan M et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science 368, 630–633 (2020).
  • (6) Hodcroft, E. B., Domman, D. B., Snyder, D. J. Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. medRxiv preprint on February 14, 2021. doi: https://doi.org/10.1101/2021.02.12.21251658
  • (7) https://www.nature.com/articles/d41586-021-00564-4
  • (8) https://www.nature.com/articles/d41586-021-01059-y
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