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BAI1 Products

(Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008].

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Featured BAI1 Categories

BAI1 Antibodies

High quality antibodies with extensive validation data.

BAI1 ELISA Kits

Reliable ELISA kits for a wide range of species.

BAI1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BAI1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), FACS
Validations
  • (4)
Cat. No. ABIN392804
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (3)
Cat. No. ABIN3181614
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, WB, ELISA, IF, ICC
Validations
  • (3)
Cat. No. ABIN6257957
Quantity 100 μL
Datasheet Datasheet

Recommended BAI1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954184
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4881934
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6385397
Quantity 96 tests
Datasheet Datasheet

Recommended BAI1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN3135045
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN3109525
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN6964229
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our BAI1 products

Zhu, Osuka, Zhang, Reichert, Yang, Kanemura, Jiang, You, Zhang, Devi, Bhattacharya, Takano, Gillespie, Macdonald, Tan, Nishikawa, Nelson, Olson, Van Meir: "BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation." in: Cancer cell, Vol. 33, Issue 6, pp. 1004-1016.e5, (2018) (PubMed).

Hochreiter-Hufford, Lee, Kinchen, Sokolowski, Arandjelovic, Call, Klibanov, Yan, Mandell, Ravichandran: "Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion." in: Nature, Vol. 497, Issue 7448, pp. 263-7, (2013) (PubMed).

Kang, Xiao, Harata, Bai, Nakazaki, Soda, Kurita, Tanaka, Komine, Izawa, Kunisaki, Setoyama, Nishimori, Natsume, Sunamura, Lozonshi, Saitoh, Tokino, Asano, Nakamura, Tani: "Antiangiogenic activity of BAI1 in vivo: implications for gene therapy of human glioblastomas." in: Cancer gene therapy, Vol. 13, Issue 4, pp. 385-92, (2006) (PubMed).

Kaur, Brat, Calkins, Van Meir: "Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression." in: The American journal of pathology, Vol. 162, Issue 1, pp. 19-27, (2002) (PubMed).

Duda, Sunamura, Lozonschi, Yokoyama, Yatsuoka, Motoi, Horii, Tani, Asano, Nakamura, Matsuno: "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis." in: British journal of cancer, Vol. 86, Issue 3, pp. 490-6, (2002) (PubMed).

Mori, Kanemura, Fujikawa, Nakano, Ikemoto, Ozaki, Matsumoto, Tamura, Yokota, Arita: "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells." in: Neuroscience research, Vol. 43, Issue 1, pp. 69-74, (2002) (PubMed).

Synonyms and alternative names related to BAI1

brain-specific angiogenesis inhibitor 1 (BAI1), adhesion G protein-coupled receptor B1 (ADGRB1), brain-specific angiogenesis inhibitor 1 (LOC100228084), adhesion G protein-coupled receptor B1 (Adgrb1), B830018M07Rik, BAI1, GDAIF, mKIAA4089, R75078

Protein level used designations for BAI1

  • brain-specific angiogenesis inhibitor 1
  • brain-specific angiogenesis inhibitor 1-like
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