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CD97 Products

(CD97)

Categories

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011].

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Featured CD97 Categories

CD97 Antibodies

High quality antibodies with extensive validation data.

CD97 ELISA Kits

Reliable ELISA kits for a wide range of species.

CD97 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CD97 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ELISA, FACS, ICC, Neut
Validations
  • (6)
Cat. No. ABIN7193255
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro)
Validations
  • (4)
Cat. No. ABIN741495
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, RNAi
Validations
  • (4)
Cat. No. ABIN560261
Quantity 100 μg
Datasheet Datasheet

Recommended CD97 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965617
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965616
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6720027
Quantity 1 kit
Datasheet Datasheet

Recommended CD97 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348745
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348744
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3091473
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CD97 products

He, Xu, Feng, Wang: "Role of CD97 small isoform in human cervical carcinoma." in: International journal of experimental pathology, Vol. 100, Issue 1, pp. 19-24, (2019) (PubMed).

Hovingh, van Gent, Hamstra, Demkes, Mooi, Pinelli: "Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells." in: PLoS ONE, Vol. 12, Issue 1, pp. e0170027, (2017) (PubMed).

Zyryanova, Schneider, Adams, Sittig, Kerner, Gebhardt, Ruffert, Glasmacher, Hepp, Punkt, Neuhaus, Hamann, Aust: "Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function." in: PLoS ONE, Vol. 9, Issue 6, pp. e100513, (2014) (PubMed).

Karpus, Veninga, Hoek, Flierman, van Buul, Vandenakker, vanBavel, Medof, van Lier, Reedquist, Hamann: "Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 7, pp. 3740-8, (2013) (PubMed).

Liu, Trojanowicz, Ye, Li, Zhang, Li, Li, Zheng, Chen: "The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma." in: PLoS ONE, Vol. 7, Issue 6, pp. e39989, (2012) (PubMed).

Becker, Wandel, Wobus, Schneider, Amasheh, Sittig, Kerner, Naumann, Hamann, Aust: "Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions." in: PLoS ONE, Vol. 5, Issue 1, pp. e8507, (2010) (PubMed).

Veninga, Becker, Hoek, Wobus, Wandel, van der Kaa, van der Valk, de Vos, Haase, Owens, van der Poll, van Lier, Verbeek, Aust, Hamann: "Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 6574-83, (2008) (PubMed).

Wang, Tian, Haino, Gao, Lake, Ward, Wang, Siebenlist, Murphy, Kelly: "Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97." in: Infection and immunity, Vol. 75, Issue 3, pp. 1144-53, (2007) (PubMed).

Abbott, Spendlove, Roversi, Fitzgibbon, Knott, Teriete, McDonnell, Handford, Lea: "Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55." in: The Journal of biological chemistry, Vol. 282, Issue 30, pp. 22023-32, (2007) (PubMed).

Galle, Sittig, Hanisch, Wobus, Wandel, Loeffler, Aust: "Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion." in: The American journal of pathology, Vol. 169, Issue 5, pp. 1802-11, (2006) (PubMed).

Synonyms and alternative names related to CD97

adhesion G protein-coupled receptor E5 (Adgre5), adhesion G protein-coupled receptor E5 (ADGRE5), AA409984, TM7LN1

Protein level used designations for CD97

  • EGF-TM7 receptor
  • CD97 antigen
  • leukocyte antigen CD97
  • seven transmembrane helix receptor
  • seven-span transmembrane protein
  • seven-transmembrane, heterodimeric receptor associated with inflammation
  • CD97 large isoform
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