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|Epitope||AA 1-100 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This CD59 antibody is un-conjugated Alternatives|
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Product Details anti-CD59 AntibodyTarget Details CD59 Application Details Handling Images
|Specificity||Rat CD59 / CD59A / MAC / IP|
|Characteristics||Produced in rabbits immunized with purified, recombinant Rat CD59 / CD59A / MAC / IP (rR CD59 / CD59A / MAC / IP, ABIN2215300 P27274, Met1-Asn100,. Total IgG was purified by Protein A affinity chromatography.|
|Purification||purified by Protein A affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Rat CD59 / CD59A / MAC / IP protein (ABIN2215300)|
Target Details CD59Product Details anti-CD59 Antibody Application Details Handling Images back to top
|Alternative Name||CD59 (CD59 Antibody Abstract)|
|Background||CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC- inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).|
Application DetailsProduct Details anti-CD59 Antibody Target Details CD59 Handling Images back to top
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat CD59 / CD59A / MAC / IP. The detection limit for Rat CD59 / CD59A / MAC / IP is approximately ≤ 0.039 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD59 Antibody Target Details CD59 Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|