anti-Human Complement Factor B antibody for Immunoprecipitation

Recommended Complement Factor B Antibody (supplied by: Log in to see )

Antigen
Complement Factor B (CFB) Antibodies
  • AHUS4
  • BF
  • BFD
  • CFAB
  • FB
  • FBI12
  • GBG
  • H2-Bf
  • PBF2
  • bf
  • Bf-1
  • Brre-Bf
  • zgc:114032
  • Bf
  • Sp152
  • bfb-A
  • Bf B
  • LOC397725
  • bf/c2
  • CFB
  • AI195813
  • AI255840
  • B
  • C2
  • Fb
  • Da1-24
  • complement factor B
  • complement factor B S homeolog
  • complement factor B L homeolog
  • CFB
  • cfb
  • bf
  • cfb.S
  • cfb.L
  • bf/c2
  • LOC100555981
  • Cfb
Reactivity
Human
209
55
46
2
1
1
1
1
1
Host
Mouse
138
88
13
6
1
Clonality
Monoclonal
Conjugate
This Complement Factor B antibody is un-conjugated
28
20
12
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
177
132
67
29
23
19
16
14
13
12
12
6
6
4
3
2
1
1
Supplier
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Catalog No. ABIN1106810
$ 467.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1106809 EIA IP WB Mouse IgG1 Log in to see M20-6 3
1 ABIN568601 ID IHC (p) IP Goat Log in to see Polyclonal 0
1 ABIN1106808 EIA IP WB Mouse IgG1 Log in to see M13-12 1
1 ABIN4299960 IA IP WB Mouse IgG1 Log in to see M13-12 0
1 ABIN2237070 IP ELISA WB Mouse IgG2b AA 26-764 Log in to see 7H80 0
1 ABIN457969 IP Goat IgG Log in to see Polyclonal 0
1 ABIN2237082 IP ELISA WB Mouse IgG1 Log in to see 13A39 0
1 ABIN2237084 IP ELISA WB Mouse IgG1 Log in to see 13A40 0
1 ABIN2896762 IF/ICC IHC IP WB Rabbit AA 35-160 Log in to see Polyclonal 0
1 ABIN2896760 IF/ICC IHC IP WB Rabbit AA 270-388 Log in to see Polyclonal 0
1 ABIN2896761 IF/ICC IHC IP WB Rabbit AA 477-600 Log in to see Polyclonal 0
1 ABIN2237080 IP ELISA WB Mouse IgG2a Log in to see 13A38 0
1 ABIN6021980 IF/ICC IHC IP WB Mouse Log in to see 0

General

Antigen Complement Factor B (CFB) Antibodies
Reactivity Human
(209), (55), (46), (2), (1), (1), (1), (1), (1)
Host Mouse
(138), (88), (13), (6), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Complement Factor B antibody is un-conjugated
(28), (20), (12), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
(177), (132), (67), (29), (23), (19), (16), (14), (13), (12), (12), (6), (6), (4), (3), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-Complement Factor B Antibody

Target Details Complement Factor B Application Details Handling References for anti-Complement Factor B antibody (ABIN1106810) Images
Specificity This antibody detects Complement factor B/Ba.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Clone P21-15
Isotype IgG2a
Plasmids, Primers & others

Target Details Complement Factor B

Product Details anti-Complement Factor B Antibody Application Details Handling References for anti-Complement Factor B antibody (ABIN1106810) Images back to top
Antigen
Alternative Name Complement Factor B (CFB Antibody Abstract)
Background Factor B is an acute-phase protein. Levels of factor B increase during inflammation. Complement factor B is a single- chain molecule of 764 amino acids (MW 90 kD), including a leader peptide of 25 amino acids. Factor B provides the catalytic subunit of the C3/C5 convertases of the alternative complement pathway. Assembly of the C3 convertase (C3bBb) requires binding of factor B to C3b (C3.H2O) and factor D-mediated cleavage of bound factor B resulting in the release of Ba (MW 33 kD). The C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60 kD) is the serine protease element of this convertase. After cleavage of C3, the C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the alternative pathway of complement activation than Ba as impaired renal filtration does directly influence Ba levels. Whereas Bb is elevated 2.2-fold in chronic renal failure (CRF) patients, plasma concentrations of Ba are 8.4-fold higher in CRF and 16-fold higher in end-stage renal disease (ESRD) patients compared to normals.In addition to complement activation, factor B fragments participate in other immunological functions.Synonyms: BF, BFD, C3/C5 convertase, CFB, Glycine-rich beta glycoprotein, PBF2, Properdin factor B
Gene ID 629
NCBI Accession NP_001701
UniProt P00751
Pathways Complement System, Proton Transport, Ribonucleoside Biosynthetic Process

Application Details

Product Details anti-Complement Factor B Antibody Target Details Complement Factor B Handling References for anti-Complement Factor B antibody (ABIN1106810) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Complement Factor B Antibody Target Details Complement Factor B Application Details References for anti-Complement Factor B antibody (ABIN1106810) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

References for anti-Complement Factor B antibody (ABIN1106810)

Product Details anti-Complement Factor B Antibody Target Details Complement Factor B Application Details Handling Images back to top
Background publications

Oppermann, Kurts, Zierz, Quentin, Weber, Götze: "Elevated plasma levels of the immunosuppressive complement fragment Ba in renal failure." in: Kidney international, Vol. 40, Issue 5, pp. 939-47, 1992

Oppermann, Baumgarten, Brandt, Gottsleben, Kurts, Götze: "Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays." in: Journal of immunological methods, Vol. 133, Issue 2, pp. 181-90, 1990

Oppermann, Haubitz, Quentin, Götze: "Complement activation in patients with renal failure as detected through the quantitation of fragments of the complement proteins C3, C5, and factor B." in: Klinische Wochenschrift, Vol. 66, Issue 18, pp. 857-64, 1988